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Assay Detail

CHEMBL1963736

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PAK4
ChEMBL ↗
1019
Total Activities
1001
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase PAK 4 (CHEMBL4482) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1019 6.06 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1993661 — — 1 8.80
CHEMBL1980995 — — 1 8.10
CHEMBL1994669 — — 1 8.10
CHEMBL1984548 — — 1 8.00
CHEMBL1974328 — — 1 8.00
CHEMBL1987034 — — 1 7.80
CHEMBL1983589 — — 1 7.70
CHEMBL1971029 — — 1 7.70
CHEMBL1986943 — — 2 7.60
CHEMBL1972290 — — 1 7.60
CHEMBL2005216 — — 1 7.60
CHEMBL1992220 — — 1 7.60
CHEMBL1974870 — — 1 7.50
CHEMBL2005509 — — 1 7.50
CHEMBL1982271 — — 1 7.50
CHEMBL1241473 — — 1 7.50
CHEMBL1994438 — — 1 7.50
CHEMBL1980407 — — 1 7.50
CHEMBL1996980 — — 1 7.40
CHEMBL1973720 — — 2 7.40
CHEMBL2006765 — — 1 7.40
CHEMBL1997924 — — 1 7.30
CHEMBL2006564 — — 1 7.30
CHEMBL1965836 — — 1 7.30
CHEMBL1969151 — — 1 7.30
CHEMBL1986855 — — 1 7.30
CHEMBL1983348 — — 1 7.20
CHEMBL302449 GO-6976 — 1 7.20
CHEMBL2006456 — — 1 7.10
CHEMBL1972339 — — 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1993661 — Ki = 1.585 nM 8.80
CHEMBL1980995 — Ki = 7.943 nM 8.10
CHEMBL1994669 — Ki = 7.943 nM 8.10
CHEMBL1984548 — Ki = 10.0 nM 8.00
CHEMBL1974328 — Ki = 10.0 nM 8.00
CHEMBL1987034 — Ki = 15.85 nM 7.80
CHEMBL1983589 — Ki = 19.95 nM 7.70
CHEMBL1971029 — Ki = 19.95 nM 7.70
CHEMBL1972290 — Ki = 25.12 nM 7.60
CHEMBL1986943 — Ki = 25.12 nM 7.60
CHEMBL1986943 — Ki = 25.12 nM 7.60
CHEMBL2005216 — Ki = 25.12 nM 7.60
CHEMBL1992220 — Ki = 25.12 nM 7.60
CHEMBL1982271 — Ki = 31.62 nM 7.50
CHEMBL1241473 — Ki = 31.62 nM 7.50
CHEMBL1994438 — Ki = 31.62 nM 7.50
CHEMBL1974870 — Ki = 31.62 nM 7.50
CHEMBL1980407 — Ki = 31.62 nM 7.50
CHEMBL2005509 — Ki = 31.62 nM 7.50
CHEMBL1973720 — Ki = 39.81 nM 7.40
CHEMBL1996980 — Ki = 39.81 nM 7.40
CHEMBL2006765 — Ki = 39.81 nM 7.40
CHEMBL1973720 — Ki = 39.81 nM 7.40
CHEMBL1965836 — Ki = 50.12 nM 7.30
CHEMBL1986855 — Ki = 50.12 nM 7.30
CHEMBL2006564 — Ki = 50.12 nM 7.30
CHEMBL1969151 — Ki = 50.12 nM 7.30
CHEMBL1997924 — Ki = 50.12 nM 7.30
CHEMBL302449 GO-6976 Ki = 63.1 nM 7.20
CHEMBL1983348 — Ki = 63.1 nM 7.20
CHEMBL1980391 RG-1530 Ki = 79.43 nM 7.10
CHEMBL2006456 — Ki = 79.43 nM 7.10
CHEMBL1976936 — Ki = 79.43 nM 7.10
CHEMBL1991063 — Ki = 79.43 nM 7.10
CHEMBL1972339 — Ki = 79.43 nM 7.10
CHEMBL1995813 — Ki = 100.0 nM 7.00
CHEMBL1998432 — Ki = 100.0 nM 7.00
CHEMBL1992363 — Ki = 100.0 nM 7.00
CHEMBL1965702 — Ki = 100.0 nM 7.00
CHEMBL1983111 — Ki = 100.0 nM 7.00
CHEMBL1991674 — Ki = 100.0 nM 7.00
CHEMBL1980562 — Ki = 125.89 nM 6.90
CHEMBL1979690 — Ki = 125.89 nM 6.90
CHEMBL475251 R-406 Ki = 125.89 nM 6.90
CHEMBL1968930 — Ki = 125.89 nM 6.90
CHEMBL1980253 — Ki = 125.89 nM 6.90
CHEMBL1967998 — Ki = 125.89 nM 6.90
CHEMBL1988581 — Ki = 158.49 nM 6.80
CHEMBL2005886 — Ki = 158.49 nM 6.80
CHEMBL1980178 — Ki = 158.49 nM 6.80