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Assay Detail

CHEMBL1963752

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: BLK
ChEMBL ↗
650
Total Activities
636
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase Blk (CHEMBL2250) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 650 6.88 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1994938 — — 1 9.10
CHEMBL1988717 — — 1 9.00
CHEMBL1993661 — — 1 9.00
CHEMBL1977148 — — 1 8.90
CHEMBL1970142 — — 1 8.80
CHEMBL1967116 — — 1 8.80
CHEMBL1980995 — — 1 8.80
CHEMBL1982466 — — 1 8.70
CHEMBL1980297 ILORASERTIB 2.0 1 8.60
CHEMBL1988387 — — 1 8.50
CHEMBL1982476 — — 1 8.50
CHEMBL1970317 — — 1 8.50
CHEMBL1969102 — — 1 8.50
CHEMBL1966514 — — 1 8.30
CHEMBL2005631 — — 1 8.30
CHEMBL1974254 — — 1 8.30
CHEMBL1989708 — — 2 8.20
CHEMBL1971947 — — 1 8.20
CHEMBL475251 R-406 2.0 1 8.20
CHEMBL1967878 CENISERTIB 2.0 1 8.10
CHEMBL306380 — — 1 8.00
CHEMBL1241473 — — 1 8.00
CHEMBL2004290 — — 1 8.00
CHEMBL1993941 — — 1 7.90
CHEMBL2002165 — — 1 7.90
CHEMBL1993243 — — 1 7.90
CHEMBL522892 DOVITINIB 3.0 1 7.90
CHEMBL1999749 — — 1 7.90
CHEMBL1979516 — — 1 7.90
CHEMBL2005886 — — 1 7.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1994938 — Ki = 0.7943 nM 9.10
CHEMBL1993661 — Ki = 1.0 nM 9.00
CHEMBL1988717 — Ki = 1.0 nM 9.00
CHEMBL1977148 — Ki = 1.259 nM 8.90
CHEMBL1967116 — Ki = 1.585 nM 8.80
CHEMBL1980995 — Ki = 1.585 nM 8.80
CHEMBL1970142 — Ki = 1.585 nM 8.80
CHEMBL1982466 — Ki = 1.995 nM 8.70
CHEMBL1980297 ILORASERTIB Ki = 2.512 nM 8.60
CHEMBL1982476 — Ki = 3.162 nM 8.50
CHEMBL1970317 — Ki = 3.162 nM 8.50
CHEMBL1988387 — Ki = 3.162 nM 8.50
CHEMBL1969102 — Ki = 3.162 nM 8.50
CHEMBL1974254 — Ki = 5.012 nM 8.30
CHEMBL2005631 — Ki = 5.012 nM 8.30
CHEMBL1966514 — Ki = 5.012 nM 8.30
CHEMBL1971947 — Ki = 6.31 nM 8.20
CHEMBL1989708 — Ki = 6.31 nM 8.20
CHEMBL475251 R-406 Ki = 6.31 nM 8.20
CHEMBL1967878 CENISERTIB Ki = 7.943 nM 8.10
CHEMBL306380 — Ki = 10.0 nM 8.00
CHEMBL1241473 — Ki = 10.0 nM 8.00
CHEMBL2004290 — Ki = 10.0 nM 8.00
CHEMBL1999749 — Ki = 12.59 nM 7.90
CHEMBL2002165 — Ki = 12.59 nM 7.90
CHEMBL522892 DOVITINIB Ki = 12.59 nM 7.90
CHEMBL1989708 — Ki = 12.59 nM 7.90
CHEMBL1993243 — Ki = 12.59 nM 7.90
CHEMBL1993941 — Ki = 12.59 nM 7.90
CHEMBL1979516 — Ki = 12.59 nM 7.90
CHEMBL2005886 — Ki = 15.85 nM 7.80
CHEMBL1969502 — Ki = 15.85 nM 7.80
CHEMBL1984162 — Ki = 15.85 nM 7.80
CHEMBL1973178 — Ki = 15.85 nM 7.80
CHEMBL1965570 — Ki = 15.85 nM 7.80
CHEMBL2001485 — Ki = 19.95 nM 7.70
CHEMBL1981725 — Ki = 19.95 nM 7.70
CHEMBL1967720 — Ki = 25.12 nM 7.60
CHEMBL1090356 — Ki = 25.12 nM 7.60
CHEMBL1994321 — Ki = 25.12 nM 7.60
CHEMBL1968590 — Ki = 31.62 nM 7.50
CHEMBL2006778 — Ki = 31.62 nM 7.50
CHEMBL1986851 — Ki = 31.62 nM 7.50
CHEMBL572878 TOZASERTIB Ki = 31.62 nM 7.50
CHEMBL2005828 — Ki = 31.62 nM 7.50
CHEMBL302449 GO-6976 Ki = 31.62 nM 7.50
CHEMBL1990583 — Ki = 31.62 nM 7.50
CHEMBL1970083 — Ki = 31.62 nM 7.50
CHEMBL1981047 — Ki = 39.81 nM 7.40
CHEMBL483158 ALISERTIB Ki = 39.81 nM 7.40