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Assay Detail

CHEMBL1963764

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM3
ChEMBL ↗
596
Total Activities
584
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase pim-3 (CHEMBL5407) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 596 5.88 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1969537 — — 1 8.10
CHEMBL1973098 — — 1 8.10
CHEMBL1974328 — — 1 8.00
CHEMBL1974870 — — 1 8.00
CHEMBL1970903 — — 1 8.00
CHEMBL1965836 — — 1 7.90
CHEMBL583144 — — 1 7.90
CHEMBL1991063 — — 1 7.80
CHEMBL244378 — — 1 7.70
CHEMBL592030 — — 1 7.50
CHEMBL226403 — — 1 7.50
CHEMBL243088 — — 1 7.50
CHEMBL2003286 — — 1 7.40
CHEMBL1974702 — — 1 7.40
CHEMBL2001920 — — 1 7.30
CHEMBL468280 — — 1 7.30
CHEMBL2000354 — — 1 7.30
CHEMBL1966808 — — 1 7.20
CHEMBL2002726 — — 1 7.20
CHEMBL1980704 — — 1 7.10
CHEMBL1988173 — — 1 7.10
CHEMBL1973348 — — 1 7.00
CHEMBL1987679 — — 1 6.90
CHEMBL1967302 — — 1 6.90
CHEMBL1982660 — — 2 6.90
CHEMBL1967887 — — 1 6.90
CHEMBL1970522 — — 1 6.80
CHEMBL1991434 — — 1 6.80
CHEMBL1966628 — — 1 6.70
CHEMBL1725279 SP-600125 — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1969537 — Ki = 7.943 nM 8.10
CHEMBL1973098 — Ki = 7.943 nM 8.10
CHEMBL1974870 — Ki = 10.0 nM 8.00
CHEMBL1970903 — Ki = 10.0 nM 8.00
CHEMBL1974328 — Ki = 10.0 nM 8.00
CHEMBL1965836 — Ki = 12.59 nM 7.90
CHEMBL583144 — Ki = 12.59 nM 7.90
CHEMBL1991063 — Ki = 15.85 nM 7.80
CHEMBL244378 — Ki = 19.95 nM 7.70
CHEMBL243088 — Ki = 31.62 nM 7.50
CHEMBL592030 — Ki = 31.62 nM 7.50
CHEMBL226403 — Ki = 31.62 nM 7.50
CHEMBL1974702 — Ki = 39.81 nM 7.40
CHEMBL2003286 — Ki = 39.81 nM 7.40
CHEMBL2001920 — Ki = 50.12 nM 7.30
CHEMBL2000354 — Ki = 50.12 nM 7.30
CHEMBL468280 — Ki = 50.12 nM 7.30
CHEMBL1966808 — Ki = 63.1 nM 7.20
CHEMBL2002726 — Ki = 63.1 nM 7.20
CHEMBL1988173 — Ki = 79.43 nM 7.10
CHEMBL1980704 — Ki = 79.43 nM 7.10
CHEMBL1973348 — Ki = 100.0 nM 7.00
CHEMBL1987679 — Ki = 125.89 nM 6.90
CHEMBL1967887 — Ki = 125.89 nM 6.90
CHEMBL1982660 — Ki = 125.89 nM 6.90
CHEMBL1967302 — Ki = 125.89 nM 6.90
CHEMBL1982660 — Ki = 125.89 nM 6.90
CHEMBL1991434 — Ki = 158.49 nM 6.80
CHEMBL1970522 — Ki = 158.49 nM 6.80
CHEMBL1725279 SP-600125 Ki = 199.53 nM 6.70
CHEMBL1966628 — Ki = 199.53 nM 6.70
CHEMBL1965131 — Ki = 251.19 nM 6.60
CHEMBL1969588 — Ki = 251.19 nM 6.60
CHEMBL2002346 — Ki = 251.19 nM 6.60
CHEMBL1999931 — Ki = 251.19 nM 6.60
CHEMBL1984788 — Ki = 251.19 nM 6.60
CHEMBL1967544 — Ki = 251.19 nM 6.60
CHEMBL1972820 — Ki = 251.19 nM 6.60
CHEMBL1989265 — Ki = 316.23 nM 6.50
CHEMBL1375418 — Ki = 316.23 nM 6.50
CHEMBL385478 — Ki = 316.23 nM 6.50
CHEMBL1969502 — Ki = 316.23 nM 6.50
CHEMBL1964444 — Ki = 316.23 nM 6.50
CHEMBL565612 SOTRASTAURIN Ki = 316.23 nM 6.50
CHEMBL1977681 — Ki = 316.23 nM 6.50
CHEMBL526133 — Ki = 316.23 nM 6.50
CHEMBL1992323 — Ki = 316.23 nM 6.50
CHEMBL513846 — Ki = 316.23 nM 6.50
CHEMBL1985074 — Ki = 316.23 nM 6.50
CHEMBL1982957 — Ki = 398.11 nM 6.40