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Assay Detail

CHEMBL1963773

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK3
ChEMBL ↗
532
Total Activities
522
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dual specificity tyrosine-phosphorylation-regulated kinase 3 (CHEMBL4575) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 532 6.14 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1974870 — — 1 8.30
CHEMBL1986943 — — 2 8.30
CHEMBL1997129 — — 1 8.10
CHEMBL2006439 — — 1 8.10
CHEMBL2001751 — — 1 8.10
CHEMBL1991063 — — 1 8.00
CHEMBL1965660 — — 2 8.00
CHEMBL1973098 — — 1 8.00
CHEMBL1964290 — — 1 8.00
CHEMBL1981079 — — 1 7.80
CHEMBL1967887 — — 1 7.60
CHEMBL1965836 — — 1 7.50
CHEMBL259922 — — 1 7.50
CHEMBL1987359 — — 1 7.40
CHEMBL340384 — — 1 7.40
CHEMBL225519 — — 1 7.30
CHEMBL1991674 — — 1 7.30
CHEMBL1682553 — — 1 7.30
CHEMBL1966628 — — 1 7.20
CHEMBL1969588 — — 1 7.20
CHEMBL1987034 — — 1 7.10
CHEMBL1971943 BAY-549 — 1 7.10
CHEMBL1966722 — — 1 7.10
CHEMBL226403 — — 1 7.10
CHEMBL1976455 — — 1 7.10
CHEMBL2003286 — — 1 7.00
CHEMBL592030 — — 1 7.00
CHEMBL1982711 — — 1 7.00
CHEMBL1997846 — — 1 7.00
CHEMBL1995813 — — 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1986943 — Ki = 5.012 nM 8.30
CHEMBL1974870 — Ki = 5.012 nM 8.30
CHEMBL1986943 — Ki = 5.012 nM 8.30
CHEMBL2001751 — Ki = 7.943 nM 8.10
CHEMBL2006439 — Ki = 7.943 nM 8.10
CHEMBL1997129 — Ki = 7.943 nM 8.10
CHEMBL1965660 — Ki = 10.0 nM 8.00
CHEMBL1965660 — Ki = 10.0 nM 8.00
CHEMBL1991063 — Ki = 10.0 nM 8.00
CHEMBL1973098 — Ki = 10.0 nM 8.00
CHEMBL1964290 — Ki = 10.0 nM 8.00
CHEMBL1981079 — Ki = 15.85 nM 7.80
CHEMBL1967887 — Ki = 25.12 nM 7.60
CHEMBL1965836 — Ki = 31.62 nM 7.50
CHEMBL259922 — Ki = 31.62 nM 7.50
CHEMBL340384 — Ki = 39.81 nM 7.40
CHEMBL1987359 — Ki = 39.81 nM 7.40
CHEMBL1682553 — Ki = 50.12 nM 7.30
CHEMBL1991674 — Ki = 50.12 nM 7.30
CHEMBL225519 — Ki = 50.12 nM 7.30
CHEMBL1966628 — Ki = 63.1 nM 7.20
CHEMBL1969588 — Ki = 63.1 nM 7.20
CHEMBL1971943 BAY-549 Ki = 79.43 nM 7.10
CHEMBL226403 — Ki = 79.43 nM 7.10
CHEMBL1966722 — Ki = 79.43 nM 7.10
CHEMBL1987034 — Ki = 79.43 nM 7.10
CHEMBL1976455 — Ki = 79.43 nM 7.10
CHEMBL2003286 — Ki = 100.0 nM 7.00
CHEMBL1982711 — Ki = 100.0 nM 7.00
CHEMBL592030 — Ki = 100.0 nM 7.00
CHEMBL1997846 — Ki = 100.0 nM 7.00
CHEMBL497151 — Ki = 125.89 nM 6.90
CHEMBL1992937 — Ki = 125.89 nM 6.90
CHEMBL1964692 — Ki = 125.89 nM 6.90
CHEMBL1994241 — Ki = 125.89 nM 6.90
CHEMBL1995813 — Ki = 125.89 nM 6.90
CHEMBL1988173 — Ki = 125.89 nM 6.90
CHEMBL2003638 — Ki = 125.89 nM 6.90
CHEMBL1978448 — Ki = 158.49 nM 6.80
CHEMBL1993548 — Ki = 158.49 nM 6.80
CHEMBL2000894 — Ki = 158.49 nM 6.80
CHEMBL396523 — Ki = 158.49 nM 6.80
CHEMBL2000354 — Ki = 158.49 nM 6.80
CHEMBL1998121 — Ki = 199.53 nM 6.70
CHEMBL1989646 — Ki = 199.53 nM 6.70
CHEMBL1965423 — Ki = 199.53 nM 6.70
CHEMBL1967544 — Ki = 199.53 nM 6.70
CHEMBL226471 — Ki = 199.53 nM 6.70
CHEMBL1990482 — Ki = 199.53 nM 6.70
CHEMBL2002726 — Ki = 251.19 nM 6.60