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Assay Detail

CHEMBL1963778

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PDGFRB
ChEMBL ↗
301
Total Activities
294
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Platelet-derived growth factor receptor beta (CHEMBL1913) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 301 6.53 9.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL196363 — — 1 9.90
CHEMBL1999414 — — 1 9.50
CHEMBL1996649 — — 1 9.40
CHEMBL1965170 — — 1 9.30
CHEMBL1980297 ILORASERTIB 2.0 1 9.30
CHEMBL1988437 — — 1 9.20
CHEMBL1972220 — — 1 9.10
CHEMBL1980995 — — 1 9.10
CHEMBL49120 PD-0166285 1.0 1 9.10
CHEMBL1989708 — — 1 9.00
CHEMBL1990885 — — 1 9.00
CHEMBL5416410 DASATINIB 4.0 1 8.90
CHEMBL2004290 — — 1 8.90
CHEMBL1983640 — — 1 8.70
CHEMBL1964441 — — 1 8.50
CHEMBL1980407 — — 1 8.50
CHEMBL223360 LINIFANIB 3.0 1 8.40
CHEMBL477772 PAZOPANIB 4.0 1 8.40
CHEMBL1336 SORAFENIB 4.0 1 8.40
CHEMBL1967878 CENISERTIB 2.0 1 8.40
CHEMBL522892 DOVITINIB 3.0 1 8.20
CHEMBL574738 AST-487 1.0 1 8.10
CHEMBL1978166 — — 2 8.10
CHEMBL1977134 — — 1 8.10
CHEMBL2007266 — — 1 8.00
CHEMBL1996646 — — 1 8.00
CHEMBL491473 CEDIRANIB 3.0 1 7.80
CHEMBL2002432 — — 1 7.80
CHEMBL1965387 — — 1 7.70
CHEMBL2004438 — — 1 7.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL196363 — Ki = 0.1259 nM 9.90
CHEMBL1999414 — Ki = 0.3162 nM 9.50
CHEMBL1996649 — Ki = 0.3981 nM 9.40
CHEMBL1980297 ILORASERTIB Ki = 0.5012 nM 9.30
CHEMBL1965170 — Ki = 0.5012 nM 9.30
CHEMBL1988437 — Ki = 0.631 nM 9.20
CHEMBL1972220 — Ki = 0.7943 nM 9.10
CHEMBL1980995 — Ki = 0.7943 nM 9.10
CHEMBL49120 PD-0166285 Ki = 0.7943 nM 9.10
CHEMBL1990885 — Ki = 1.0 nM 9.00
CHEMBL1989708 — Ki = 1.0 nM 9.00
CHEMBL2004290 — Ki = 1.259 nM 8.90
CHEMBL5416410 DASATINIB Ki = 1.259 nM 8.90
CHEMBL1983640 — Ki = 1.995 nM 8.70
CHEMBL1964441 — Ki = 3.162 nM 8.50
CHEMBL1980407 — Ki = 3.162 nM 8.50
CHEMBL477772 PAZOPANIB Ki = 3.981 nM 8.40
CHEMBL1336 SORAFENIB Ki = 3.981 nM 8.40
CHEMBL1967878 CENISERTIB Ki = 3.981 nM 8.40
CHEMBL223360 LINIFANIB Ki = 3.981 nM 8.40
CHEMBL522892 DOVITINIB Ki = 6.31 nM 8.20
CHEMBL574738 AST-487 Ki = 7.943 nM 8.10
CHEMBL1978166 — Ki = 7.943 nM 8.10
CHEMBL1978166 — Ki = 7.943 nM 8.10
CHEMBL1977134 — Ki = 7.943 nM 8.10
CHEMBL2007266 — Ki = 10.0 nM 8.00
CHEMBL1996646 — Ki = 10.0 nM 8.00
CHEMBL491473 CEDIRANIB Ki = 15.85 nM 7.80
CHEMBL2002432 — Ki = 15.85 nM 7.80
CHEMBL1965387 — Ki = 19.95 nM 7.70
CHEMBL2004438 — Ki = 25.12 nM 7.60
CHEMBL1989267 — Ki = 31.62 nM 7.50
CHEMBL1980329 — Ki = 39.81 nM 7.40
CHEMBL1979690 — Ki = 39.81 nM 7.40
CHEMBL1980391 RG-1530 Ki = 50.12 nM 7.30
CHEMBL941 IMATINIB Ki = 50.12 nM 7.30
CHEMBL475251 R-406 Ki = 50.12 nM 7.30
CHEMBL124660 TANDUTINIB Ki = 50.12 nM 7.30
CHEMBL1988581 — Ki = 63.1 nM 7.20
CHEMBL1983923 — Ki = 63.1 nM 7.20
CHEMBL1983111 — Ki = 63.1 nM 7.20
CHEMBL101253 VATALANIB Ki = 79.43 nM 7.10
CHEMBL1993661 — Ki = 79.43 nM 7.10
CHEMBL1999484 — Ki = 125.89 nM 6.90
CHEMBL1996176 — Ki = 125.89 nM 6.90
CHEMBL1997892 — Ki = 158.49 nM 6.80
CHEMBL1984236 — Ki = 158.49 nM 6.80
CHEMBL1996176 — Ki = 158.49 nM 6.80
CHEMBL406845 — Ki = 199.53 nM 6.70
CHEMBL2006564 — Ki = 199.53 nM 6.70