Compound Detail
CHEMBL1965387
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Nc1n[nH]c2c(OCCCn3cccc3)ccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Basic Information
| ChEMBL ID | CHEMBL1965387 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GSYNTOXSBKQRAW-UHFFFAOYSA-N |
8
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
501.0
MW (Da)
6.38
ALogP
5
HBA
4
HBD
110.0
PSA (Ų)
0.19
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 8 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 7.8 | 7.8 | 15.8 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | Ki | 7.7 | 7.7 | 19.9 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | Ki | 7.5 | 7.5 | 31.6 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | Ki | 7.3 | 7.3 | 50.1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | Ki | 7.2 | 7.2 | 63.1 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Aurora kinase B CHEMBL2185 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine