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Assay Detail

CHEMBL1963805

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PDGFRA
ChEMBL ↗
328
Total Activities
319
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 328 6.19 10.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL196363 — — 1 10.10
CHEMBL1980297 ILORASERTIB 2.0 1 9.10
CHEMBL1999414 — — 1 8.90
CHEMBL1965170 — — 1 8.80
CHEMBL49120 PD-0166285 1.0 1 8.70
CHEMBL1972220 — — 1 8.60
CHEMBL2004290 — — 1 8.60
CHEMBL1964441 — — 1 8.60
CHEMBL1989708 — — 1 8.50
CHEMBL1983640 — — 1 8.50
CHEMBL1988437 — — 1 8.20
CHEMBL1980995 — — 1 8.10
CHEMBL1996649 — — 1 8.10
CHEMBL1967878 CENISERTIB 2.0 1 8.00
CHEMBL491473 CEDIRANIB 3.0 1 8.00
CHEMBL5416410 DASATINIB 4.0 1 8.00
CHEMBL2004716 — — 1 7.90
CHEMBL1977134 — — 1 7.80
CHEMBL1978166 — — 2 7.70
CHEMBL1986851 — — 1 7.60
CHEMBL1989267 — — 1 7.40
CHEMBL1983923 — — 1 7.40
CHEMBL223360 LINIFANIB 3.0 1 7.30
CHEMBL1988581 — — 1 7.30
CHEMBL1970317 — — 1 7.30
CHEMBL124660 TANDUTINIB 2.0 1 7.20
CHEMBL1996646 — — 1 7.10
CHEMBL574738 AST-487 1.0 1 7.10
CHEMBL1965387 — — 1 7.10
CHEMBL2004438 — — 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL196363 — Ki = 0.07943 nM 10.10
CHEMBL1980297 ILORASERTIB Ki = 0.7943 nM 9.10
CHEMBL1999414 — Ki = 1.259 nM 8.90
CHEMBL1965170 — Ki = 1.585 nM 8.80
CHEMBL49120 PD-0166285 Ki = 1.995 nM 8.70
CHEMBL2004290 — Ki = 2.512 nM 8.60
CHEMBL1964441 — Ki = 2.512 nM 8.60
CHEMBL1972220 — Ki = 2.512 nM 8.60
CHEMBL1989708 — Ki = 3.162 nM 8.50
CHEMBL1983640 — Ki = 3.162 nM 8.50
CHEMBL1988437 — Ki = 6.31 nM 8.20
CHEMBL1996649 — Ki = 7.943 nM 8.10
CHEMBL1980995 — Ki = 7.943 nM 8.10
CHEMBL491473 CEDIRANIB Ki = 10.0 nM 8.00
CHEMBL5416410 DASATINIB Ki = 10.0 nM 8.00
CHEMBL1967878 CENISERTIB Ki = 10.0 nM 8.00
CHEMBL2004716 — Ki = 12.59 nM 7.90
CHEMBL1977134 — Ki = 15.85 nM 7.80
CHEMBL1978166 — Ki = 19.95 nM 7.70
CHEMBL1978166 — Ki = 19.95 nM 7.70
CHEMBL1986851 — Ki = 25.12 nM 7.60
CHEMBL1983923 — Ki = 39.81 nM 7.40
CHEMBL1989267 — Ki = 39.81 nM 7.40
CHEMBL223360 LINIFANIB Ki = 50.12 nM 7.30
CHEMBL1988581 — Ki = 50.12 nM 7.30
CHEMBL1970317 — Ki = 50.12 nM 7.30
CHEMBL124660 TANDUTINIB Ki = 63.1 nM 7.20
CHEMBL2004438 — Ki = 79.43 nM 7.10
CHEMBL1996646 — Ki = 79.43 nM 7.10
CHEMBL1965387 — Ki = 79.43 nM 7.10
CHEMBL574738 AST-487 Ki = 79.43 nM 7.10
CHEMBL2007266 — Ki = 100.0 nM 7.00
CHEMBL482967 CYC-116 Ki = 100.0 nM 7.00
CHEMBL1983111 — Ki = 100.0 nM 7.00
CHEMBL1991734 — Ki = 100.0 nM 7.00
CHEMBL1980407 — Ki = 125.89 nM 6.90
CHEMBL2004637 — Ki = 158.49 nM 6.80
CHEMBL24828 VANDETANIB Ki = 158.49 nM 6.80
CHEMBL2006564 — Ki = 158.49 nM 6.80
CHEMBL1967998 — Ki = 158.49 nM 6.80
CHEMBL941 IMATINIB Ki = 158.49 nM 6.80
CHEMBL475251 R-406 Ki = 199.53 nM 6.70
CHEMBL1979690 — Ki = 199.53 nM 6.70
CHEMBL1973359 — Ki = 199.53 nM 6.70
CHEMBL1997892 — Ki = 199.53 nM 6.70
CHEMBL1990223 — Ki = 199.53 nM 6.70
CHEMBL1997335 — Ki = 199.53 nM 6.70
CHEMBL406845 — Ki = 251.19 nM 6.60
CHEMBL2001257 — Ki = 251.19 nM 6.60
CHEMBL215152 DEFOSBARASERTIB Ki = 251.19 nM 6.60