Compound Detail
CHEMBL2007266
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Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCCn4cccc4)c4[nH]nc(N)c34)cc2)c1
Basic Information
| ChEMBL ID | CHEMBL2007266 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AYXVSCVVQIADBF-UHFFFAOYSA-N |
13
Targets
13
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
498.6
MW (Da)
6.17
ALogP
5
HBA
4
HBD
110.0
PSA (Ų)
0.19
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 13 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 7.9 | 7.9 | 12.6 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | Ki | 7.8 | 7.8 | 15.8 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | Ki | 7.7 | 7.7 | 19.9 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | Ki | 7.0 | 7.0 | 100.0 | 1 |
| Aurora kinase B CHEMBL2185 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Leukocyte tyrosine kinase receptor CHEMBL5627 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| BDNF/NT-3 growth factors receptor CHEMBL4898 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| ALK tyrosine kinase receptor CHEMBL4247 | Ki | 5.3 | 5.3 | 5011.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine