Compound Detail
CHEMBL2002432
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Basic Information
| ChEMBL ID | CHEMBL2002432 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KVXUSGCDEMAYHI-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
4.16
ALogP
6
HBA
2
HBD
62.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | Ki | 7.8 | 7.8 | 15.8 | 1 |
| Tyrosine-protein kinase ABL1 CHEMBL1862 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 2 CHEMBL2964 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Cyclin-dependent kinase 7 CHEMBL3055 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | Ki | = | 15.85 | nM | 7.8 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Tyrosine-protein kinase Lck | Ki | = | 79.43 | nM | 7.1 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Tyrosine-protein kinase ABL1 | Ki | = | 79.43 | nM | 7.1 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Macrophage colony-stimulating factor 1 receptor | Ki | = | 630.96 | nM | 6.2 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Dual specificity mitogen-activated protein kinase kinase 2 | Ki | = | 1258.93 | nM | 5.9 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Cyclin-dependent kinase 7 | Ki | = | 1584.89 | nM | 5.8 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
Data from ChEMBL 36 via Core Engine