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Assay Detail

CHEMBL1963785

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ABL1
ChEMBL ↗
786
Total Activities
768
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase ABL1 (CHEMBL1862) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 786 6.49 9.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1977148 — — 1 9.60
CHEMBL1982476 — — 1 9.30
CHEMBL49120 PD-0166285 1.0 1 9.30
CHEMBL1974254 — — 1 9.20
CHEMBL2002165 — — 1 9.10
CHEMBL1993941 — — 1 8.90
CHEMBL1967116 — — 1 8.80
CHEMBL1969102 — — 1 8.80
CHEMBL1972220 — — 1 8.80
CHEMBL2006778 — — 1 8.70
CHEMBL1970317 — — 1 8.70
CHEMBL1965170 — — 1 8.70
CHEMBL2005631 — — 1 8.70
CHEMBL1982466 — — 1 8.60
CHEMBL1981047 — — 1 8.60
CHEMBL2004716 — — 1 8.60
CHEMBL1988387 — — 1 8.60
CHEMBL2004290 — — 1 8.50
CHEMBL1988437 — — 1 8.50
CHEMBL1980297 ILORASERTIB 2.0 1 8.50
CHEMBL1970142 — — 1 8.40
CHEMBL1997617 — — 1 8.40
CHEMBL1997822 — — 1 8.40
CHEMBL1999414 — — 1 8.10
CHEMBL1996649 — — 1 8.10
CHEMBL1993661 — — 1 8.10
CHEMBL1997924 — — 1 8.00
CHEMBL1996979 — — 1 8.00
CHEMBL1970083 — — 1 8.00
CHEMBL1996066 — — 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1977148 — Ki = 0.2512 nM 9.60
CHEMBL1982476 — Ki = 0.5012 nM 9.30
CHEMBL49120 PD-0166285 Ki = 0.5012 nM 9.30
CHEMBL1974254 — Ki = 0.631 nM 9.20
CHEMBL2002165 — Ki = 0.7943 nM 9.10
CHEMBL1993941 — Ki = 1.259 nM 8.90
CHEMBL1967116 — Ki = 1.585 nM 8.80
CHEMBL1969102 — Ki = 1.585 nM 8.80
CHEMBL1972220 — Ki = 1.585 nM 8.80
CHEMBL2005631 — Ki = 1.995 nM 8.70
CHEMBL1970317 — Ki = 1.995 nM 8.70
CHEMBL1965170 — Ki = 1.995 nM 8.70
CHEMBL2006778 — Ki = 1.995 nM 8.70
CHEMBL1988387 — Ki = 2.512 nM 8.60
CHEMBL1981047 — Ki = 2.512 nM 8.60
CHEMBL1982466 — Ki = 2.512 nM 8.60
CHEMBL2004716 — Ki = 2.512 nM 8.60
CHEMBL1988437 — Ki = 3.162 nM 8.50
CHEMBL1980297 ILORASERTIB Ki = 3.162 nM 8.50
CHEMBL2004290 — Ki = 3.162 nM 8.50
CHEMBL1997822 — Ki = 3.981 nM 8.40
CHEMBL1970142 — Ki = 3.981 nM 8.40
CHEMBL1997617 — Ki = 3.981 nM 8.40
CHEMBL1999414 — Ki = 7.943 nM 8.10
CHEMBL1993661 — Ki = 7.943 nM 8.10
CHEMBL1996649 — Ki = 7.943 nM 8.10
CHEMBL1996066 — Ki = 10.0 nM 8.00
CHEMBL1970083 — Ki = 10.0 nM 8.00
CHEMBL1996979 — Ki = 10.0 nM 8.00
CHEMBL1997924 — Ki = 10.0 nM 8.00
CHEMBL1989267 — Ki = 12.59 nM 7.90
CHEMBL1988717 — Ki = 15.85 nM 7.80
CHEMBL1081312 — Ki = 15.85 nM 7.80
CHEMBL572878 TOZASERTIB Ki = 15.85 nM 7.80
CHEMBL574738 AST-487 Ki = 25.12 nM 7.60
CHEMBL508928 — Ki = 25.12 nM 7.60
CHEMBL2001485 — Ki = 25.12 nM 7.60
CHEMBL1998585 — Ki = 31.62 nM 7.50
CHEMBL1966514 — Ki = 31.62 nM 7.50
CHEMBL24828 VANDETANIB Ki = 31.62 nM 7.50
CHEMBL1967878 CENISERTIB Ki = 39.81 nM 7.40
CHEMBL1988075 — Ki = 39.81 nM 7.40
CHEMBL1982465 — Ki = 39.81 nM 7.40
CHEMBL1976134 — Ki = 50.12 nM 7.30
CHEMBL1988300 — Ki = 50.12 nM 7.30
CHEMBL1982957 — Ki = 50.12 nM 7.30
CHEMBL1980329 — Ki = 50.12 nM 7.30
CHEMBL1968590 — Ki = 50.12 nM 7.30
CHEMBL941 IMATINIB Ki = 50.12 nM 7.30
CHEMBL1974664 — Ki = 63.1 nM 7.20