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Assay Detail

CHEMBL1963801

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PTK2
ChEMBL ↗
738
Total Activities
722
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Focal adhesion kinase 1 (CHEMBL2695) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 738 6.04 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1084546 PF-00562271 1.0 1 9.20
CHEMBL458997 — — 1 8.80
CHEMBL1981133 — — 1 8.70
CHEMBL1971029 — — 1 8.60
CHEMBL1993661 — — 1 8.50
CHEMBL1997924 — — 1 8.30
CHEMBL1241473 — — 1 8.20
CHEMBL1983111 — — 1 8.10
CHEMBL1164180 — — 1 7.90
CHEMBL1980391 RG-1530 1.0 1 7.90
CHEMBL271381 — — 1 7.60
CHEMBL1981047 — — 1 7.60
CHEMBL1984038 — — 1 7.60
CHEMBL1992527 — — 1 7.50
CHEMBL2007421 — — 1 7.50
CHEMBL461876 — — 1 7.40
CHEMBL1984162 — — 1 7.40
CHEMBL1967116 — — 1 7.40
CHEMBL1825138 — — 3 7.20
CHEMBL1989708 — — 2 7.20
CHEMBL1972220 — — 1 7.20
CHEMBL1979690 — — 1 7.20
CHEMBL1967998 — — 1 7.10
CHEMBL1998585 — — 1 7.10
CHEMBL1988387 — — 1 7.10
CHEMBL1999484 — — 1 7.10
CHEMBL1987034 — — 1 7.00
CHEMBL1980995 — — 1 7.00
CHEMBL1964692 — — 1 7.00
CHEMBL1983268 ENTRECTINIB 4.0 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1084546 PF-00562271 Ki = 0.631 nM 9.20
CHEMBL458997 — Ki = 1.585 nM 8.80
CHEMBL1981133 — Ki = 1.995 nM 8.70
CHEMBL1971029 — Ki = 2.512 nM 8.60
CHEMBL1993661 — Ki = 3.162 nM 8.50
CHEMBL1997924 — Ki = 5.012 nM 8.30
CHEMBL1241473 — Ki = 6.31 nM 8.20
CHEMBL1983111 — Ki = 7.943 nM 8.10
CHEMBL1980391 RG-1530 Ki = 12.59 nM 7.90
CHEMBL1164180 — Ki = 12.59 nM 7.90
CHEMBL1984038 — Ki = 25.12 nM 7.60
CHEMBL1981047 — Ki = 25.12 nM 7.60
CHEMBL271381 — Ki = 25.12 nM 7.60
CHEMBL1992527 — Ki = 31.62 nM 7.50
CHEMBL2007421 — Ki = 31.62 nM 7.50
CHEMBL1967116 — Ki = 39.81 nM 7.40
CHEMBL461876 — Ki = 39.81 nM 7.40
CHEMBL1984162 — Ki = 39.81 nM 7.40
CHEMBL1825138 — Ki = 63.1 nM 7.20
CHEMBL1989708 — Ki = 63.1 nM 7.20
CHEMBL1972220 — Ki = 63.1 nM 7.20
CHEMBL1979690 — Ki = 63.1 nM 7.20
CHEMBL1988387 — Ki = 79.43 nM 7.10
CHEMBL1998585 — Ki = 79.43 nM 7.10
CHEMBL1967998 — Ki = 79.43 nM 7.10
CHEMBL1989708 — Ki = 79.43 nM 7.10
CHEMBL1999484 — Ki = 79.43 nM 7.10
CHEMBL1964692 — Ki = 100.0 nM 7.00
CHEMBL1983268 ENTRECTINIB Ki = 100.0 nM 7.00
CHEMBL1980995 — Ki = 100.0 nM 7.00
CHEMBL1987034 — Ki = 100.0 nM 7.00
CHEMBL1984711 — Ki = 100.0 nM 7.00
CHEMBL483158 ALISERTIB Ki = 125.89 nM 6.90
CHEMBL1980297 ILORASERTIB Ki = 125.89 nM 6.90
CHEMBL1977138 — Ki = 125.89 nM 6.90
CHEMBL2005886 — Ki = 125.89 nM 6.90
CHEMBL242865 — Ki = 125.89 nM 6.90
CHEMBL2006765 — Ki = 158.49 nM 6.80
CHEMBL2002165 — Ki = 158.49 nM 6.80
CHEMBL1988581 — Ki = 158.49 nM 6.80
CHEMBL1968406 — Ki = 199.53 nM 6.70
CHEMBL1967720 — Ki = 199.53 nM 6.70
CHEMBL1164265 — Ki = 199.53 nM 6.70
CHEMBL411903 — Ki = 199.53 nM 6.70
CHEMBL1983715 — Ki = 251.19 nM 6.60
CHEMBL1973516 — Ki = 251.19 nM 6.60
CHEMBL2004716 — Ki = 251.19 nM 6.60
CHEMBL1979883 — Ki = 251.19 nM 6.60
CHEMBL1973516 — Ki = 251.19 nM 6.60
CHEMBL1974328 — Ki = 316.23 nM 6.50