Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1963804

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MELK
ChEMBL ↗
575
Total Activities
566
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Maternal embryonic leucine zipper kinase (CHEMBL4578) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 575 6.63 9.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.50
CHEMBL2005718 — — 1 9.00
CHEMBL1984548 — — 1 8.90
CHEMBL1998432 — — 1 8.90
CHEMBL1994669 — — 1 8.80
CHEMBL1994438 — — 1 8.80
CHEMBL1972290 — — 1 8.70
CHEMBL1969151 — — 1 8.50
CHEMBL1973720 — — 2 8.50
CHEMBL1984162 — — 1 8.40
CHEMBL1986943 — — 2 8.30
CHEMBL1983589 — — 1 8.30
CHEMBL1987448 — — 1 8.30
CHEMBL2001751 — — 1 8.30
CHEMBL1973540 — — 1 8.20
CHEMBL1985723 — — 1 8.20
CHEMBL1971172 — — 1 7.80
CHEMBL1998159 — — 1 7.80
CHEMBL1980253 — — 1 7.70
CHEMBL1976936 — — 1 7.60
CHEMBL2005216 — — 1 7.60
CHEMBL1993413 — — 1 7.50
CHEMBL522892 DOVITINIB 3.0 1 7.50
CHEMBL1241473 — — 1 7.40
CHEMBL572878 TOZASERTIB 2.0 1 7.40
CHEMBL1992363 — — 1 7.40
CHEMBL1966204 — — 1 7.30
CHEMBL1987073 — — 1 7.30
CHEMBL2007044 — — 1 7.30
CHEMBL1969523 — — 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.3162 nM 9.50
CHEMBL2005718 — Ki = 1.0 nM 9.00
CHEMBL1984548 — Ki = 1.259 nM 8.90
CHEMBL1998432 — Ki = 1.259 nM 8.90
CHEMBL1994669 — Ki = 1.585 nM 8.80
CHEMBL1994438 — Ki = 1.585 nM 8.80
CHEMBL1972290 — Ki = 1.995 nM 8.70
CHEMBL1973720 — Ki = 3.162 nM 8.50
CHEMBL1969151 — Ki = 3.162 nM 8.50
CHEMBL1973720 — Ki = 3.162 nM 8.50
CHEMBL1984162 — Ki = 3.981 nM 8.40
CHEMBL1986943 — Ki = 5.012 nM 8.30
CHEMBL1983589 — Ki = 5.012 nM 8.30
CHEMBL2001751 — Ki = 5.012 nM 8.30
CHEMBL1987448 — Ki = 5.012 nM 8.30
CHEMBL1986943 — Ki = 5.012 nM 8.30
CHEMBL1973540 — Ki = 6.31 nM 8.20
CHEMBL1985723 — Ki = 6.31 nM 8.20
CHEMBL1971172 — Ki = 15.85 nM 7.80
CHEMBL1998159 — Ki = 15.85 nM 7.80
CHEMBL1980253 — Ki = 19.95 nM 7.70
CHEMBL1976936 — Ki = 25.12 nM 7.60
CHEMBL2005216 — Ki = 25.12 nM 7.60
CHEMBL522892 DOVITINIB Ki = 31.62 nM 7.50
CHEMBL1993413 — Ki = 31.62 nM 7.50
CHEMBL572878 TOZASERTIB Ki = 39.81 nM 7.40
CHEMBL1241473 — Ki = 39.81 nM 7.40
CHEMBL1992363 — Ki = 39.81 nM 7.40
CHEMBL2007044 — Ki = 50.12 nM 7.30
CHEMBL1987073 — Ki = 50.12 nM 7.30
CHEMBL1966204 — Ki = 50.12 nM 7.30
CHEMBL1969523 — Ki = 50.12 nM 7.30
CHEMBL2004716 — Ki = 63.1 nM 7.20
CHEMBL1998953 — Ki = 63.1 nM 7.20
CHEMBL2002446 — Ki = 63.1 nM 7.20
CHEMBL2005475 — Ki = 79.43 nM 7.10
CHEMBL1965507 — Ki = 79.43 nM 7.10
CHEMBL1974870 — Ki = 79.43 nM 7.10
CHEMBL1967878 CENISERTIB Ki = 79.43 nM 7.10
CHEMBL1084546 PF-00562271 Ki = 79.43 nM 7.10
CHEMBL1992231 — Ki = 79.43 nM 7.10
CHEMBL1972346 — Ki = 79.43 nM 7.10
CHEMBL398951 — Ki = 79.43 nM 7.10
CHEMBL2002479 — Ki = 79.43 nM 7.10
CHEMBL1987009 — Ki = 100.0 nM 7.00
CHEMBL411903 — Ki = 100.0 nM 7.00
CHEMBL1988387 — Ki = 100.0 nM 7.00
CHEMBL1993661 — Ki = 100.0 nM 7.00
CHEMBL1995813 — Ki = 100.0 nM 7.00
CHEMBL2005886 — Ki = 125.89 nM 6.90