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Assay Detail

CHEMBL1963834

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK2
ChEMBL ↗
655
Total Activities
646
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase MARK2 (CHEMBL3831) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 655 5.93 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 8.10
CHEMBL1984162 — — 1 7.80
CHEMBL1241473 — — 1 7.80
CHEMBL1971029 — — 1 7.80
CHEMBL302449 GO-6976 — 1 7.60
CHEMBL1970317 — — 1 7.40
CHEMBL1987034 — — 1 7.40
CHEMBL1987054 — — 1 7.30
CHEMBL1998121 — — 1 7.30
CHEMBL592030 — — 1 7.30
CHEMBL1973540 — — 1 7.20
CHEMBL1999931 — — 1 7.20
CHEMBL1981047 — — 1 7.20
CHEMBL1982957 — — 1 7.10
CHEMBL1997129 — — 1 7.10
CHEMBL1990583 — — 1 7.10
CHEMBL2005886 — — 1 7.10
CHEMBL2000393 — — 1 7.10
CHEMBL2001751 — — 1 7.10
CHEMBL590109 — — 1 7.10
CHEMBL1970104 — — 2 7.10
CHEMBL1998159 — — 1 7.10
CHEMBL522892 DOVITINIB 3.0 1 6.90
CHEMBL1973395 — — 1 6.90
CHEMBL1967116 — — 1 6.80
CHEMBL1982711 — — 1 6.80
CHEMBL1970903 — — 1 6.80
CHEMBL1970083 — — 1 6.80
CHEMBL1976134 — — 1 6.70
CHEMBL1972158 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 7.943 nM 8.10
CHEMBL1984162 — Ki = 15.85 nM 7.80
CHEMBL1241473 — Ki = 15.85 nM 7.80
CHEMBL1971029 — Ki = 15.85 nM 7.80
CHEMBL302449 GO-6976 Ki = 25.12 nM 7.60
CHEMBL1970317 — Ki = 39.81 nM 7.40
CHEMBL1987034 — Ki = 39.81 nM 7.40
CHEMBL1987054 — Ki = 50.12 nM 7.30
CHEMBL1998121 — Ki = 50.12 nM 7.30
CHEMBL592030 — Ki = 50.12 nM 7.30
CHEMBL1973540 — Ki = 63.1 nM 7.20
CHEMBL1999931 — Ki = 63.1 nM 7.20
CHEMBL1981047 — Ki = 63.1 nM 7.20
CHEMBL1997129 — Ki = 79.43 nM 7.10
CHEMBL2005886 — Ki = 79.43 nM 7.10
CHEMBL1990583 — Ki = 79.43 nM 7.10
CHEMBL1998159 — Ki = 79.43 nM 7.10
CHEMBL2000393 — Ki = 79.43 nM 7.10
CHEMBL2001751 — Ki = 79.43 nM 7.10
CHEMBL590109 — Ki = 79.43 nM 7.10
CHEMBL1970104 — Ki = 79.43 nM 7.10
CHEMBL1970104 — Ki = 79.43 nM 7.10
CHEMBL1982957 — Ki = 79.43 nM 7.10
CHEMBL1973395 — Ki = 125.89 nM 6.90
CHEMBL522892 DOVITINIB Ki = 125.89 nM 6.90
CHEMBL1970903 — Ki = 158.49 nM 6.80
CHEMBL1982711 — Ki = 158.49 nM 6.80
CHEMBL1970083 — Ki = 158.49 nM 6.80
CHEMBL1967116 — Ki = 158.49 nM 6.80
CHEMBL1992922 — Ki = 199.53 nM 6.70
CHEMBL1082440 — Ki = 199.53 nM 6.70
CHEMBL1972158 — Ki = 199.53 nM 6.70
CHEMBL2000335 — Ki = 199.53 nM 6.70
CHEMBL1976134 — Ki = 199.53 nM 6.70
CHEMBL1985095 — Ki = 199.53 nM 6.70
CHEMBL1990885 — Ki = 199.53 nM 6.70
CHEMBL398951 — Ki = 251.19 nM 6.60
CHEMBL2001998 — Ki = 251.19 nM 6.60
CHEMBL1991063 — Ki = 251.19 nM 6.60
CHEMBL1965507 — Ki = 251.19 nM 6.60
CHEMBL1980297 ILORASERTIB Ki = 251.19 nM 6.60
CHEMBL1974870 — Ki = 251.19 nM 6.60
CHEMBL1964399 — Ki = 251.19 nM 6.60
CHEMBL1997617 — Ki = 251.19 nM 6.60
CHEMBL1969523 — Ki = 316.23 nM 6.50
CHEMBL1967878 CENISERTIB Ki = 316.23 nM 6.50
CHEMBL1975128 — Ki = 316.23 nM 6.50
CHEMBL1988594 — Ki = 316.23 nM 6.50
CHEMBL1084546 PF-00562271 Ki = 316.23 nM 6.50
CHEMBL1967720 — Ki = 316.23 nM 6.50