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Assay Detail

CHEMBL1964102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC42BPA
ChEMBL ↗
760
Total Activities
747
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase MRCK alpha (CHEMBL4516) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 760 5.88 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 8.40
CHEMBL1974870 — — 2 8.10
CHEMBL1991063 — — 1 8.10
CHEMBL1969588 — — 1 7.80
CHEMBL1991674 — — 1 7.70
CHEMBL2000271 — — 1 7.60
CHEMBL1997534 — — 1 7.60
CHEMBL1986943 — — 2 7.50
CHEMBL1969561 — — 1 7.50
CHEMBL1965836 — — 1 7.40
CHEMBL1997846 — — 1 7.40
CHEMBL1970903 — — 1 7.30
CHEMBL1986499 — — 1 7.30
CHEMBL1975256 — — 1 7.20
CHEMBL1995813 — — 1 7.20
CHEMBL1982361 — — 1 7.20
CHEMBL1965845 — — 1 7.10
CHEMBL1979252 — — 1 7.10
CHEMBL2002726 — — 1 7.10
CHEMBL1971943 BAY-549 — 1 7.10
CHEMBL1980489 — — 1 7.10
CHEMBL1992796 — — 1 7.00
CHEMBL1979554 — — 1 7.00
CHEMBL1993661 — — 1 7.00
CHEMBL1988608 — — 1 7.00
CHEMBL2006439 — — 1 6.90
CHEMBL1975900 — — 1 6.90
CHEMBL220241 GSK-269962A — 1 6.80
CHEMBL1994864 — — 1 6.80
CHEMBL1970879 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 3.981 nM 8.40
CHEMBL1991063 — Ki = 7.943 nM 8.10
CHEMBL1974870 — Ki = 7.943 nM 8.10
CHEMBL1974870 — Ki = 7.943 nM 8.10
CHEMBL1969588 — Ki = 15.85 nM 7.80
CHEMBL1991674 — Ki = 19.95 nM 7.70
CHEMBL2000271 — Ki = 25.12 nM 7.60
CHEMBL1997534 — Ki = 25.12 nM 7.60
CHEMBL1986943 — Ki = 31.62 nM 7.50
CHEMBL1986943 — Ki = 31.62 nM 7.50
CHEMBL1969561 — Ki = 31.62 nM 7.50
CHEMBL1997846 — Ki = 39.81 nM 7.40
CHEMBL1965836 — Ki = 39.81 nM 7.40
CHEMBL1970903 — Ki = 50.12 nM 7.30
CHEMBL1986499 — Ki = 50.12 nM 7.30
CHEMBL1975256 — Ki = 63.1 nM 7.20
CHEMBL1982361 — Ki = 63.1 nM 7.20
CHEMBL1995813 — Ki = 63.1 nM 7.20
CHEMBL2002726 — Ki = 79.43 nM 7.10
CHEMBL1965845 — Ki = 79.43 nM 7.10
CHEMBL1979252 — Ki = 79.43 nM 7.10
CHEMBL1980489 — Ki = 79.43 nM 7.10
CHEMBL1971943 BAY-549 Ki = 79.43 nM 7.10
CHEMBL1988608 — Ki = 100.0 nM 7.00
CHEMBL1992796 — Ki = 100.0 nM 7.00
CHEMBL1979554 — Ki = 100.0 nM 7.00
CHEMBL1993661 — Ki = 100.0 nM 7.00
CHEMBL2006439 — Ki = 125.89 nM 6.90
CHEMBL1975900 — Ki = 125.89 nM 6.90
CHEMBL220241 GSK-269962A Ki = 158.49 nM 6.80
CHEMBL1994864 — Ki = 158.49 nM 6.80
CHEMBL1986970 — Ki = 158.49 nM 6.80
CHEMBL1970879 — Ki = 158.49 nM 6.80
CHEMBL1983449 — Ki = 199.53 nM 6.70
CHEMBL50894 ALSTERPAULLONE Ki = 199.53 nM 6.70
CHEMBL1972158 — Ki = 199.53 nM 6.70
CHEMBL2000685 — Ki = 199.53 nM 6.70
CHEMBL1682553 — Ki = 199.53 nM 6.70
CHEMBL2005936 — Ki = 199.53 nM 6.70
CHEMBL1966524 — Ki = 199.53 nM 6.70
CHEMBL1996111 — Ki = 199.53 nM 6.70
CHEMBL1990254 — Ki = 251.19 nM 6.60
CHEMBL1975128 — Ki = 251.19 nM 6.60
CHEMBL1975418 — Ki = 251.19 nM 6.60
CHEMBL1996780 — Ki = 251.19 nM 6.60
CHEMBL1975128 — Ki = 251.19 nM 6.60
CHEMBL2004692 — Ki = 251.19 nM 6.60
CHEMBL340384 — Ki = 251.19 nM 6.60
CHEMBL1981725 — Ki = 316.23 nM 6.50
CHEMBL1976240 — Ki = 316.23 nM 6.50