Assay Detail
Binding
CHEMBL2415220
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Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 4.54 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644697 | SODIUM CYANIDE | — | 1 | 4.70 |
| CHEMBL1644696 | SODIUM CYANATE | — | 1 | 4.52 |
| CHEMBL1644699 | SODIUM HYDROSULFIDE | — | 1 | 4.40 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
| CHEMBL68253 | SULFAMATE | — | 1 | - |
| CHEMBL355001 | SULFAMIDE | — | 1 | - |
| CHEMBL1780189 | SODIUM TETRAFLUOROBORATE | — | 1 | - |
| CHEMBL1644700 | SODIUM PERCHLORATE | — | 1 | - |
| CHEMBL233406 | SODIUM SULFATE ANHYDROUS | 4.0 | 1 | - |
| CHEMBL1689285 | SODIUM BISULFITE | -1.0 | 1 | - |
| CHEMBL93268 | SODIUM NITRITE | 4.0 | 1 | - |
| CHEMBL364571 | PHENYLARSONIC ACID | — | 1 | - |
| CHEMBL186314 | SODIUM CARBONATE | 4.0 | 1 | - |
| CHEMBL1353 | SODIUM BICARBONATE | 4.0 | 1 | - |
| CHEMBL89295 | SODIUM AZIDE | — | 1 | - |
| CHEMBL1644028 | THIOCYANATE SODIUM | -1.0 | 1 | - |
| CHEMBL1644695 | SODIUM IODIDE | 4.0 | 1 | - |
| CHEMBL1644694 | SODIUM BROMIDE | 3.0 | 1 | - |
| CHEMBL1200574 | SODIUM CHLORIDE | 4.0 | 1 | - |
| CHEMBL1528 | SODIUM FLUORIDE | 4.0 | 1 | - |
| CHEMBL1644698 | SODIUM NITRATE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644697 | SODIUM CYANIDE | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL1644696 | SODIUM CYANATE | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL1644699 | SODIUM HYDROSULFIDE | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 23100000.0 | nM | - |
| CHEMBL68253 | SULFAMATE | Ki | = | 390000.0 | nM | - |
| CHEMBL355001 | SULFAMIDE | Ki | = | 1130000.0 | nM | - |
| CHEMBL1780189 | SODIUM TETRAFLUOROBORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL1644700 | SODIUM PERCHLORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL233406 | SODIUM SULFATE ANHYDROUS | Ki | > | 200000000.0 | nM | - |
| CHEMBL1689285 | SODIUM BISULFITE | Ki | = | 89000000.0 | nM | - |
| CHEMBL93268 | SODIUM NITRITE | Ki | = | 63000000.0 | nM | - |
| CHEMBL364571 | PHENYLARSONIC ACID | Ki | = | 49200000.0 | nM | - |
| CHEMBL186314 | SODIUM CARBONATE | Ki | = | 73000000.0 | nM | - |
| CHEMBL1353 | SODIUM BICARBONATE | Ki | = | 85000000.0 | nM | - |
| CHEMBL89295 | SODIUM AZIDE | Ki | = | 1510000.0 | nM | - |
| CHEMBL1644028 | THIOCYANATE SODIUM | Ki | = | 200000.0 | nM | - |
| CHEMBL1644695 | SODIUM IODIDE | Ki | = | 26000000.0 | nM | - |
| CHEMBL1644694 | SODIUM BROMIDE | Ki | = | 63000000.0 | nM | - |
| CHEMBL1200574 | SODIUM CHLORIDE | Ki | = | 200000000.0 | nM | - |
| CHEMBL1528 | SODIUM FLUORIDE | Ki | > | 300000000.0 | nM | - |
| CHEMBL1644698 | SODIUM NITRATE | Ki | = | 35000000.0 | nM | - |