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Assay Detail

CHEMBL2415221

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
Pan P, Vermelho AB, Scozzafava A, Parkkila S, Capasso C, Supuran CT.
Bioorg Med Chem (2013) 21 : 4472 -4476
PubMed 23790722 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 34 5.56 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1644697 SODIUM CYANIDE 1 6.30
CHEMBL1644699 SODIUM HYDROSULFIDE 1 6.22
CHEMBL1644696 SODIUM CYANATE 1 6.16
CHEMBL89295 SODIUM AZIDE 1 5.92
CHEMBL68253 SULFAMATE 1 4.68
CHEMBL448089 SODIUM SELENOCYANATE 1 4.07
CHEMBL471869 SODIUM TELLURATE 1 -
CHEMBL1780189 SODIUM TETRAFLUOROBORATE 1 -
CHEMBL364571 PHENYLARSONIC ACID 1 -
CHEMBL111016 SODIUM PYROSULFATE 1 -
CHEMBL450079 SODIUM PYROPHOSPHATE -1.0 1 -
CHEMBL294467 SODIUM VANADATE 1 -
CHEMBL1076681 SODIUM TETRABORATE 1 -
CHEMBL444819 SODIUM PERRHENATE 1 -
CHEMBL1081267 SODIUM PERRUTHENATE 1 -
CHEMBL502764 SODIUM PERSULFATE 1 -
CHEMBL233406 SODIUM SULFATE ANHYDROUS 4.0 1 -
CHEMBL1644700 SODIUM PERCHLORATE 1 -
CHEMBL1528 SODIUM FLUORIDE 4.0 1 -
CHEMBL1200574 SODIUM CHLORIDE 4.0 1 -
CHEMBL1644694 SODIUM BROMIDE 3.0 1 -
CHEMBL1644695 SODIUM IODIDE 4.0 1 -
CHEMBL1353 SODIUM BICARBONATE 4.0 1 -
CHEMBL186314 SODIUM CARBONATE 4.0 1 -
CHEMBL1644698 SODIUM NITRATE 2.0 1 -
CHEMBL93268 SODIUM NITRITE 4.0 1 -
CHEMBL1689285 SODIUM BISULFITE -1.0 1 -
CHEMBL445433 SODIUM STANNATE 1 -
CHEMBL1076628 SODIUM DIOXIDOTRIOXOOSMIUM 1 -
CHEMBL114503 SODIUM SELENATE 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1644697 SODIUM CYANIDE Ki = 500.0 nM 6.30
CHEMBL1644699 SODIUM HYDROSULFIDE Ki = 600.0 nM 6.22
CHEMBL1644696 SODIUM CYANATE Ki = 700.0 nM 6.16
CHEMBL89295 SODIUM AZIDE Ki = 1200.0 nM 5.92
CHEMBL68253 SULFAMATE Ki = 21000.0 nM 4.68
CHEMBL448089 SODIUM SELENOCYANATE Ki = 85000.0 nM 4.07
CHEMBL111016 SODIUM PYROSULFATE Ki = 990000.0 nM -
CHEMBL21485 PHENYLBORONIC ACID Ki = 58600000.0 nM -
CHEMBL450079 SODIUM PYROPHOSPHATE Ki = 25770000.0 nM -
CHEMBL294467 SODIUM VANADATE Ki = 540000.0 nM -
CHEMBL1076681 SODIUM TETRABORATE Ki = 640000.0 nM -
CHEMBL444819 SODIUM PERRHENATE Ki = 110000.0 nM -
CHEMBL1081267 SODIUM PERRUTHENATE Ki = 101000.0 nM -
CHEMBL502764 SODIUM PERSULFATE Ki = 107000.0 nM -
CHEMBL233406 SODIUM SULFATE ANHYDROUS Ki = 63000000.0 nM -
CHEMBL1644700 SODIUM PERCHLORATE Ki > 200000000.0 nM -
CHEMBL1780189 SODIUM TETRAFLUOROBORATE Ki > 200000000.0 nM -
CHEMBL450253 SODIUM FLUOROSULFATE Ki = 790000.0 nM -
CHEMBL1644701 SODIUM IMINODISULFATE Ki = 310000.0 nM -
CHEMBL355001 SULFAMIDE Ki = 310000.0 nM -
CHEMBL364571 PHENYLARSONIC ACID Ki = 31700000.0 nM -
CHEMBL471869 SODIUM TELLURATE Ki = 660000.0 nM -
CHEMBL1528 SODIUM FLUORIDE Ki > 300000000.0 nM -
CHEMBL1200574 SODIUM CHLORIDE Ki = 6000000.0 nM -
CHEMBL1644694 SODIUM BROMIDE Ki = 4000000.0 nM -
CHEMBL1644695 SODIUM IODIDE Ki = 300000.0 nM -
CHEMBL1353 SODIUM BICARBONATE Ki = 12000000.0 nM -
CHEMBL186314 SODIUM CARBONATE Ki = 15000000.0 nM -
CHEMBL1644698 SODIUM NITRATE Ki = 7000000.0 nM -
CHEMBL93268 SODIUM NITRITE Ki = 8400000.0 nM -
CHEMBL1689285 SODIUM BISULFITE Ki = 18000000.0 nM -
CHEMBL445433 SODIUM STANNATE Ki = 570000.0 nM -
CHEMBL1076628 SODIUM DIOXIDOTRIOXOOSMIUM Ki = 920000.0 nM -
CHEMBL114503 SODIUM SELENATE Ki = 118000000.0 nM -