Assay Detail
Functional
CHEMBL3392939
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DNDI: Cytotoxicity in Vitro, 96 hour, in mouse macrophages (infected-amastigotes)
100
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 4.61 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.00 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 5.37 |
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 5.36 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 5.20 |
| CHEMBL3392933 | — | — | 1 | 5.19 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 5.14 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 4.95 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 4.64 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 4.61 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 1 | 4.61 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 4.59 |
| CHEMBL570 | TRIFLUPROMAZINE | 4.0 | 1 | 4.55 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 4.52 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 1 | 4.50 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 4.50 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.50 |
| CHEMBL487366 | — | — | 1 | 4.49 |
| CHEMBL1169388 | — | — | 1 | 4.49 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 4.49 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 4.44 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 4.44 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 4.42 |
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | 4.40 |
| CHEMBL437765 | RIFAMYCIN | 4.0 | 1 | 4.38 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 4.25 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.20 |
| CHEMBL436921 | — | — | 1 | 4.17 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 4.17 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.06 |
| CHEMBL415087 | CLOPERASTINE | 2.0 | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL1366 | AURANOFIN | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL3392933 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 11310.0 | nM | 4.95 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 22860.0 | nM | 4.64 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 24540.0 | nM | 4.61 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 24630.0 | nM | 4.61 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 25790.0 | nM | 4.59 |
| CHEMBL570 | TRIFLUPROMAZINE | IC50 | = | 28380.0 | nM | 4.55 |
| CHEMBL490 | PAROXETINE | IC50 | = | 30360.0 | nM | 4.52 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 31360.0 | nM | 4.50 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 31760.0 | nM | 4.50 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 31870.0 | nM | 4.50 |
| CHEMBL809 | SERTRALINE | IC50 | = | 32650.0 | nM | 4.49 |
| CHEMBL1169388 | — | IC50 | = | 32330.0 | nM | 4.49 |
| CHEMBL487366 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 36050.0 | nM | 4.44 |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 37970.0 | nM | 4.42 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 40120.0 | nM | 4.40 |
| CHEMBL437765 | RIFAMYCIN | IC50 | = | 41620.0 | nM | 4.38 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 56450.0 | nM | 4.25 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 62740.0 | nM | 4.20 |
| CHEMBL436921 | — | IC50 | = | 67500.0 | nM | 4.17 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 67620.0 | nM | 4.17 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 77380.0 | nM | 4.11 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 90940.0 | nM | 4.04 |
| CHEMBL1449676 | ORNIDAZOLE | IC50 | > | 135970.0 | nM | - |
| CHEMBL3392934 | — | IC50 | > | 34810.0 | nM | - |
| CHEMBL3392935 | — | IC50 | > | 167310.0 | nM | - |
| CHEMBL3392936 | — | IC50 | > | 90220.0 | nM | - |
| CHEMBL1257030 | LONIDAMINE | IC50 | > | 93410.0 | nM | - |
| CHEMBL106 | FLUCONAZOLE | IC50 | > | 97950.0 | nM | - |
| CHEMBL3039774 | — | IC50 | > | 7800.0 | nM | - |
| CHEMBL1163 | ATAZANAVIR | IC50 | > | 37460.0 | nM | - |
| CHEMBL1323 | DARUNAVIR | IC50 | > | 54780.0 | nM | - |
| CHEMBL1479 | DANAZOL | IC50 | > | 29630.0 | nM | - |
| CHEMBL729 | LOPINAVIR | IC50 | > | 47710.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 117540.0 | nM | - |
| CHEMBL296480 | — | IC50 | > | 44720.0 | nM | - |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | > | 59450.0 | nM | - |
| CHEMBL277535 | BIFONAZOLE | IC50 | > | 32220.0 | nM | - |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 125440.0 | nM | - |
| CHEMBL1043 | DAPSONE | IC50 | > | 120820.0 | nM | - |
| CHEMBL183041 | — | IC50 | > | 49780.0 | nM | - |
| CHEMBL1140 | NIACINAMIDE | IC50 | > | 245650.0 | nM | - |