Assay Detail
Binding
CHEMBL4018625
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Inhibition of recombinant human FGFR1 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.19 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 9.15 |
| CHEMBL4074407 | — | — | 1 | 7.97 |
| CHEMBL4073545 | — | — | 1 | 7.83 |
| CHEMBL4067871 | — | — | 1 | 7.79 |
| CHEMBL4062877 | — | — | 1 | 7.75 |
| CHEMBL4082721 | — | — | 1 | 7.60 |
| CHEMBL4075917 | — | — | 1 | 7.60 |
| CHEMBL4076118 | — | — | 1 | 7.55 |
| CHEMBL4084388 | — | — | 1 | 7.49 |
| CHEMBL4094883 | — | — | 1 | 7.31 |
| CHEMBL4105329 | — | — | 1 | 7.25 |
| CHEMBL4077448 | — | — | 1 | 7.20 |
| CHEMBL4100031 | — | — | 1 | 7.18 |
| CHEMBL4077119 | — | — | 1 | 7.04 |
| CHEMBL4086068 | — | — | 1 | 6.89 |
| CHEMBL4084547 | — | — | 1 | 6.78 |
| CHEMBL4095830 | — | — | 1 | 6.77 |
| CHEMBL4078176 | — | — | 1 | 6.49 |
| CHEMBL4062871 | — | — | 1 | 6.38 |
| CHEMBL4071491 | — | — | 1 | 6.36 |
| CHEMBL4060706 | — | — | 1 | 6.34 |
| CHEMBL4101542 | — | — | 1 | 5.42 |
| CHEMBL4082023 | — | — | 1 | - |
| CHEMBL4102447 | — | — | 1 | - |
| CHEMBL4092280 | — | — | 1 | - |
| CHEMBL4063010 | — | — | 1 | - |
| CHEMBL4075768 | — | — | 1 | - |
| CHEMBL4091460 | — | — | 1 | - |
| CHEMBL4101681 | — | — | 1 | - |
| CHEMBL4100109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4074407 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL4073545 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL4067871 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL4062877 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4082721 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL4075917 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL4076118 | — | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL4084388 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL4094883 | — | IC50 | = | 48.8 | nM | 7.31 |
| CHEMBL4105329 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL4077448 | — | IC50 | = | 63.5 | nM | 7.20 |
| CHEMBL4100031 | — | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL4077119 | — | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL4086068 | — | IC50 | = | 127.9 | nM | 6.89 |
| CHEMBL4084547 | — | IC50 | = | 167.3 | nM | 6.78 |
| CHEMBL4095830 | — | IC50 | = | 168.3 | nM | 6.77 |
| CHEMBL4078176 | — | IC50 | = | 327.4 | nM | 6.49 |
| CHEMBL4062871 | — | IC50 | = | 418.4 | nM | 6.38 |
| CHEMBL4071491 | — | IC50 | = | 437.3 | nM | 6.36 |
| CHEMBL4060706 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL4101542 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4083543 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4064545 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4082577 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4102355 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4068491 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4100109 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4101681 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4091460 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4075768 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4063010 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4092280 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4102447 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4082023 | — | IC50 | > | 1000.0 | nM | - |