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Compound Detail

CHEMBL1344339

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CC/C(=C\C=C\[C@@H]1C=C[C@@H]2CCC[C@H]2[C@@H]1C(=O)c1ccc[nH]1)[C@@H]1O[C@@H]([C@@H](C)C(=O)[O-])CC[C@@H]1C.[Na+]

Basic Information

ChEMBL ID CHEMBL1344339
Phase Preclinical
Structure Type MOL
InChI Key CTADJXGYSIFIAD-AAHXXMDQSA-M
Parent Compound CHEMBL1617249
Active Moiety CHEMBL1617249
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

465.6
MW (Da)
6.21
ALogP
3
HBA
2
HBD
79.4
PSA (Ų)
0.27
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H38NNaO4
MW 487.62
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 1.60

Activity Summary

EC50 6 meas. best 6.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Streptokinase A
CHEMBL1293228
EC50 6.9 6.9 127.0 1
Streptococcus
CHEMBL612313
EC50 6.83 6.83 147.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 6.7 6.7 202.0 1
Zinc finger protein mex-5
CHEMBL1293319
EC50 5.93 5.93 1165.0 1
Unchecked
CHEMBL612545
EC50 4.85 4.845 14164.0 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine