Compound Detail
CHEMBL1425183
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1425183 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RVEYUPORRVWHSU-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1626278 |
| Active Moiety | CHEMBL1626278 |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
358.3
MW (Da)
5.05
ALogP
1
HBA
0
HBD
8.8
PSA (Ų)
0.58
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.55
EC50 1 meas. best 5.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Zinc finger protein GLI1 CHEMBL5007 | IC50 | 5.55 | 5.55 | 2790.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.36 | 5.36 | 4370.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.59 | 4.535 | 25760.0 | 2 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.36 | 4.36 | 43566.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Zinc finger protein GLI1 | IC50 | = | 2790.0 | nM | 5.55 | PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SU... | - |
| Unchecked | EC50 | = | 4370.0 | nM | 5.36 | PUBCHEM_BIOASSAY: A cytotoxicity screen of small molecule inhibitors of the PhoP... | - |
| Unchecked | IC50 | = | 25760.0 | nM | 4.59 | PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of t... | - |
| Unchecked | IC50 | = | 33310.0 | nM | 4.48 | PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in S... | - |
| NON-PROTEIN TARGET | IC50 | = | 43566.0 | nM | 4.36 | PubChem BioAssay. Dose response counterscreen for inhibitors of viability of lat... | - |
Data from ChEMBL 36 via Core Engine