Compound Detail
CHEMBL1484234
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Basic Information
| ChEMBL ID | CHEMBL1484234 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NJYRQXQFIDSGOX-UHFFFAOYSA-N |
5
Targets
7
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
267.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.88
EC50 2 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.88 | 5.48 | 1320.0 | 2 |
| SUMO-activating enzyme CHEMBL2095174 | IC50 | 5.59 | 5.33 | 2590.0 | 2 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 5.17 | 5.17 | 6733.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.75 | 4.75 | 17908.0 | 1 |
| Tyrosyl-DNA phosphodiesterase 2 CHEMBL2169736 | IC50 | 4.3 | 4.3 | 50018.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1320.0 | nM | 5.88 | PubChem BioAssay. Counterscreen for inhibitors of LEDGF/p75-dependent integratio... | - |
| SUMO-activating enzyme | IC50 | = | 2590.0 | nM | 5.59 | PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of... | - |
| Zinc finger protein mex-5 | EC50 | = | 6733.0 | nM | 5.17 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Unchecked | IC50 | = | 8213.0 | nM | 5.08 | PubChem BioAssay. TR-FRET-based biochemical high throughput dose response assay ... | - |
| SUMO-activating enzyme | IC50 | = | 8600.0 | nM | 5.07 | PUBCHEM_BIOASSAY: uHTS HTRF assay for identification of inhibitors of SUMOylatio... | - |
| RNA-binding protein pos-1 | EC50 | = | 17908.0 | nM | 4.75 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Tyrosyl-DNA phosphodiesterase 2 | IC50 | = | 50018.0 | nM | 4.3 | PubChem BioAssay. Epi Absorbance-based biochemical high throughput dose response... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4296182 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4296182 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4296182 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4296182 | Staphylococcus aureus | 1 |
| - | 10.6019/CHEMBL4296182 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4296182 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4296182 | Cryptococcus neoformans | 1 |
Data from ChEMBL 36 via Core Engine