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Compound Detail

CHEMBL1535539

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Cc1nn(-c2ccccc2)c2c1C(c1ccc(O)c(O)c1)N1C(=N2)C(Nc2ccccc2)=Nc2ccccc21

Basic Information

ChEMBL ID CHEMBL1535539
Phase Preclinical
Structure Type MOL
InChI Key NWCSVPLYCSMGDA-UHFFFAOYSA-N
5
Targets
7
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

512.6
MW (Da)
6.39
ALogP
8
HBA
3
HBD
98.3
PSA (Ų)
0.24
QED
2
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H24N6O2
MW 512.57
Aromatic Rings 5
Heavy Atoms 39
NP-Likeness -0.89

Activity Summary

EC50 4 meas. best 6.11
IC50 3 meas. best 5.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Streptococcus sp. 'group A'
CHEMBL612389
EC50 6.11 6.11 772.0 1
Streptokinase A
CHEMBL1293228
EC50 5.87 5.845 1363.0 2
Unchecked
CHEMBL612545
IC50 5.82 5.82 1501.0 1
Sphingosine 1-phosphate receptor 2
CHEMBL2955
IC50 5.33 5.155 4684.0 2
Streptococcus
CHEMBL612313
EC50 5.23 5.23 5878.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine