Compound Detail
CHEMBL15511
ENROFLOXACIN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL15511 |
| Name | ENROFLOXACIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | SPFYMRJSYKOXGV-UHFFFAOYSA-N |
4
Targets
7
Activities
2
Assay Types
0
PK Parameters
20
Publications
7
Known Names
Molecular Properties
359.4
MW (Da)
2.32
ALogP
5
HBA
1
HBD
65.8
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 4 meas. best 6.54
EC50 3 meas. best 5.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.54 | 6.3225 | 290.0 | 4 |
| Streptococcus CHEMBL612313 | EC50 | 5.99 | 5.99 | 1036.0 | 1 |
| Streptococcus sp. 'group A' CHEMBL612389 | EC50 | 5.92 | 5.92 | 1215.0 | 1 |
| Streptokinase A CHEMBL1293228 | EC50 | 5.89 | 5.89 | 1291.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 290.0 | nM | 6.54 | PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in S... | - |
| Unchecked | IC50 | = | 460.0 | nM | 6.34 | PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi... | - |
| Unchecked | IC50 | = | 520.0 | nM | 6.28 | PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of t... | - |
| Unchecked | IC50 | = | 740.0 | nM | 6.13 | PUBCHEM_BIOASSAY: A Counter Screen to identiry small molecule screen for inhibit... | - |
| Streptococcus | EC50 | = | 1036.0 | nM | 5.99 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... | - |
| Streptococcus sp. 'group A' | EC50 | = | 1215.0 | nM | 5.92 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptokinase A | EC50 | = | 1291.0 | nM | 5.89 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
Literature References
Data from ChEMBL 36 via Core Engine