Compound Detail
CHEMBL269410
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Basic Information
| ChEMBL ID | CHEMBL269410 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IYNXMRJUAJBGGM-UHFFFAOYSA-N |
6
Targets
7
Activities
2
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
238.2
MW (Da)
2.07
ALogP
3
HBA
1
HBD
63.4
PSA (Ų)
0.61
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.54
EC50 2 meas. best 4.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 5.54 | 5.54 | 2903.0 | 1 |
| Protein Rev CHEMBL1293282 | IC50 | 5.1 | 5.1 | 7863.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.98 | 4.98 | 10509.0 | 1 |
| Heat shock 70 kDa protein 1A CHEMBL5460 | IC50 | 4.91 | 4.91 | 12400.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.77 | 4.77 | 17023.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.62 | 4.62 | 24000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Ka | - | - | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 2903.0 | nM | 5.54 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Protein Rev | IC50 | = | 7863.0 | nM | 5.1 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarizati... | - |
| Zinc finger protein mex-5 | EC50 | = | 10509.0 | nM | 4.98 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Heat shock 70 kDa protein 1A | IC50 | = | 12400.0 | nM | 4.91 | PUBCHEM_BIOASSAY: High Throughput Screening Assay for Hsp70 Inhibitors. (Class o... | - |
| RNA-binding protein pos-1 | EC50 | = | 17023.0 | nM | 4.77 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 24000.0 | nM | 4.62 | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetyla... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10843222 | 10.1016/s0960-894x(00)00161-x | Unchecked | 2 |
| 10843222 | 10.1016/s0960-894x(00)00161-x | Lysosomal acid glucosylceramidase | 1 |
Data from ChEMBL 36 via Core Engine