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Compound Detail

CHEMBL3191871

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O=C(O)c1ccc(N/N=C/c2ccc(-c3cc(Cl)ccc3Cl)o2)cc1

Basic Information

ChEMBL ID CHEMBL3191871
Phase Preclinical
Structure Type MOL
InChI Key HBVFSUVRAAPAKQ-UFFVCSGVSA-N
5
Targets
7
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

375.2
MW (Da)
5.40
ALogP
4
HBA
2
HBD
74.8
PSA (Ų)
0.46
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H12Cl2N2O3
MW 375.21
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -1.47

Activity Summary

EC50 6 meas. best 6.92
IC50 1 meas. best 5.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.92 6.5533 121.0 3
Induced myeloid leukemia cell differentiation protein Mcl-1
CHEMBL4361
IC50 5.66 5.66 2165.9 1
Streptokinase A
CHEMBL1293228
EC50 5.61 5.61 2485.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.61 5.61 2435.0 1
Streptococcus
CHEMBL612313
EC50 5.58 5.58 2609.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine