Compound Detail
CHEMBL558448
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Basic Information
| ChEMBL ID | CHEMBL558448 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMAPGSSLWYRDFG-UHFFFAOYSA-N |
6
Targets
7
Activities
1
Assay Types
4
PK Parameters
12
Publications
0
Known Names
Molecular Properties
469.9
MW (Da)
4.29
ALogP
6
HBA
2
HBD
81.0
PSA (Ų)
0.46
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 9.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| THP-1 CHEMBL614245 | IC50 | 9.36 | 9.36 | 0.4 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 9.0 | 9.0 | 1.0 | 2 |
| Blood CHEMBL613416 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 4.8 | 4.8 | 16000.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 4.64 | 4.64 | 22700.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 4612.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 6.167 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 81.0 | % | Rattus norvegicus |
| T1/2 | 3.8 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| THP-1 | IC50 | = | 0.44 | nM | 9.36 | Inhibition of LPS-induced TNFalpha release in human THP1 cells after 3 hrs | 19574047 |
| Mitogen-activated protein kinase 14 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by ... | 19574047 |
| Mitogen-activated protein kinase 14 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1... | 20138761 |
| Blood | IC50 | = | 1.1 | nM | 8.96 | Inhibition of TNF-alpha-stimulated IL8 production in human whole blood incubated... | 19574047 |
| Cytochrome P450 2C9 | IC50 | = | 8400.0 | nM | 5.08 | Inhibition of CYP2C9 | 19574047 |
| Cytochrome P450 2C19 | IC50 | = | 16000.0 | nM | 4.8 | Inhibition of CYP2C19 | 19574047 |
| Cytochrome P450 2D6 | IC50 | = | 22700.0 | nM | 4.64 | Inhibition of CYP2D6 | 19574047 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Rattus norvegicus | 11 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | No relevant target | 3 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Plasma | 2 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Mitogen-activated protein kinase 14 | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | THP-1 | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Blood | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Cytochrome P450 2C9 | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Cytochrome P450 2C19 | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | Cytochrome P450 2D6 | 1 |
| 19574047 | 10.1016/j.bmcl.2009.06.058 | ADMET | 1 |
| 20138761 | 10.1016/j.bmcl.2010.01.059 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine