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Assay Detail

CHEMBL1963689

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MATK
ChEMBL ↗
461
Total Activities
456
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Megakaryocyte-associated tyrosine-protein kinase (CHEMBL4175) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 461 6.23 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980297 ILORASERTIB 2.0 1 7.40
CHEMBL1993661 — — 1 7.30
CHEMBL1967878 CENISERTIB 2.0 1 7.20
CHEMBL1978448 — — 1 7.10
CHEMBL1991395 — — 1 7.10
CHEMBL1084546 PF-00562271 1.0 1 7.00
CHEMBL1978099 — — 1 6.90
CHEMBL1998585 — — 1 6.80
CHEMBL1988838 — — 1 6.80
CHEMBL1973540 — — 1 6.70
CHEMBL2004716 — — 1 6.60
CHEMBL1987034 — — 1 6.50
CHEMBL1989708 — — 1 6.50
CHEMBL422897 — — 1 6.50
CHEMBL1964692 — — 1 6.40
CHEMBL243088 — — 1 6.40
CHEMBL539474 — — 1 6.40
CHEMBL244378 — — 1 6.30
CHEMBL1725279 SP-600125 — 1 6.30
CHEMBL1988594 — — 1 6.20
CHEMBL271381 — — 1 6.20
CHEMBL1983111 — — 1 6.20
CHEMBL1969372 — — 1 6.10
CHEMBL1985092 — — 1 6.10
CHEMBL196363 — — 1 6.10
CHEMBL2005886 — — 1 6.00
CHEMBL1980896 — — 1 6.00
CHEMBL2004544 — — 1 6.00
CHEMBL1984162 — — 1 6.00
CHEMBL17370 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980297 ILORASERTIB Ki = 39.81 nM 7.40
CHEMBL1993661 — Ki = 50.12 nM 7.30
CHEMBL1967878 CENISERTIB Ki = 63.1 nM 7.20
CHEMBL1978448 — Ki = 79.43 nM 7.10
CHEMBL1991395 — Ki = 79.43 nM 7.10
CHEMBL1084546 PF-00562271 Ki = 100.0 nM 7.00
CHEMBL1978099 — Ki = 125.89 nM 6.90
CHEMBL1988838 — Ki = 158.49 nM 6.80
CHEMBL1998585 — Ki = 158.49 nM 6.80
CHEMBL1973540 — Ki = 199.53 nM 6.70
CHEMBL2004716 — Ki = 251.19 nM 6.60
CHEMBL1987034 — Ki = 316.23 nM 6.50
CHEMBL422897 — Ki = 316.23 nM 6.50
CHEMBL1989708 — Ki = 316.23 nM 6.50
CHEMBL243088 — Ki = 398.11 nM 6.40
CHEMBL539474 — Ki = 398.11 nM 6.40
CHEMBL1964692 — Ki = 398.11 nM 6.40
CHEMBL1725279 SP-600125 Ki = 501.19 nM 6.30
CHEMBL244378 — Ki = 501.19 nM 6.30
CHEMBL1988594 — Ki = 630.96 nM 6.20
CHEMBL271381 — Ki = 630.96 nM 6.20
CHEMBL1983111 — Ki = 630.96 nM 6.20
CHEMBL196363 — Ki = 794.33 nM 6.10
CHEMBL1969372 — Ki = 794.33 nM 6.10
CHEMBL1985092 — Ki = 794.33 nM 6.10
CHEMBL1980896 — Ki = 1000.0 nM 6.00
CHEMBL1984162 — Ki = 1000.0 nM 6.00
CHEMBL2004544 — Ki = 1000.0 nM 6.00
CHEMBL2005886 — Ki = 1000.0 nM 6.00
CHEMBL17370 — Ki = 1000.0 nM 6.00
CHEMBL1970104 — Ki = 1258.93 nM 5.90
CHEMBL1970104 — Ki = 1258.93 nM 5.90
CHEMBL246970 — Ki = 1584.89 nM 5.80
CHEMBL1965507 — Ki = 1584.89 nM 5.80
CHEMBL1991674 — Ki = 1584.89 nM 5.80
CHEMBL1979883 — Ki = 1584.89 nM 5.80
CHEMBL1966143 — Ki = 1584.89 nM 5.80
CHEMBL1990885 — Ki = 1584.89 nM 5.80
CHEMBL508928 — Ki = 1584.89 nM 5.80
CHEMBL1991429 — Ki = 1584.89 nM 5.80
CHEMBL404367 — Ki = 1584.89 nM 5.80
CHEMBL1968103 — Ki = 1995.26 nM 5.70
CHEMBL1976090 — Ki = 1995.26 nM 5.70
CHEMBL1996817 — Ki = 1995.26 nM 5.70
CHEMBL583144 — Ki = 1995.26 nM 5.70
CHEMBL2006715 — Ki = 1995.26 nM 5.70
CHEMBL1983449 — Ki = 1995.26 nM 5.70
CHEMBL1979516 — Ki = 1995.26 nM 5.70
CHEMBL262433 — Ki > 1995.26 nM -
CHEMBL1983932 — Ki > 1995.26 nM -