Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1963750

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TAO1
ChEMBL ↗
890
Total Activities
877
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase TAO1 (CHEMBL5261) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 890 5.78 8.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49120 PD-0166285 1.0 1 8.20
CHEMBL1980995 — — 1 8.00
CHEMBL2006715 — — 1 7.80
CHEMBL1987034 — — 1 7.70
CHEMBL1967998 — — 1 7.60
CHEMBL1984847 — — 1 7.60
CHEMBL191003 JNJ-7706621 — 1 7.60
CHEMBL1993661 — — 1 7.60
CHEMBL1998159 — — 1 7.50
CHEMBL1981725 — — 1 7.40
CHEMBL1979690 — — 1 7.30
CHEMBL2000832 — — 1 7.20
CHEMBL2006564 — — 1 7.20
CHEMBL1983070 — — 1 7.20
CHEMBL1971029 — — 1 7.10
CHEMBL572878 TOZASERTIB 2.0 1 7.10
CHEMBL396523 — — 1 7.10
CHEMBL1967878 CENISERTIB 2.0 1 7.10
CHEMBL1992306 — — 1 7.10
CHEMBL1825138 — — 3 7.00
CHEMBL244378 — — 1 7.00
CHEMBL1973516 — — 2 7.00
CHEMBL1967116 — — 1 7.00
CHEMBL1983111 — — 1 7.00
CHEMBL2005631 — — 1 7.00
CHEMBL1999414 — — 1 6.90
CHEMBL1997924 — — 1 6.90
CHEMBL2001751 — — 1 6.90
CHEMBL1979577 — — 1 6.90
CHEMBL1988163 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49120 PD-0166285 Ki = 6.31 nM 8.20
CHEMBL1980995 — Ki = 10.0 nM 8.00
CHEMBL2006715 — Ki = 15.85 nM 7.80
CHEMBL1987034 — Ki = 19.95 nM 7.70
CHEMBL1984847 — Ki = 25.12 nM 7.60
CHEMBL1993661 — Ki = 25.12 nM 7.60
CHEMBL1967998 — Ki = 25.12 nM 7.60
CHEMBL191003 JNJ-7706621 Ki = 25.12 nM 7.60
CHEMBL1998159 — Ki = 31.62 nM 7.50
CHEMBL1981725 — Ki = 39.81 nM 7.40
CHEMBL1979690 — Ki = 50.12 nM 7.30
CHEMBL2000832 — Ki = 63.1 nM 7.20
CHEMBL2006564 — Ki = 63.1 nM 7.20
CHEMBL1983070 — Ki = 63.1 nM 7.20
CHEMBL1967878 CENISERTIB Ki = 79.43 nM 7.10
CHEMBL396523 — Ki = 79.43 nM 7.10
CHEMBL1971029 — Ki = 79.43 nM 7.10
CHEMBL572878 TOZASERTIB Ki = 79.43 nM 7.10
CHEMBL1992306 — Ki = 79.43 nM 7.10
CHEMBL1973516 — Ki = 100.0 nM 7.00
CHEMBL244378 — Ki = 100.0 nM 7.00
CHEMBL1967116 — Ki = 100.0 nM 7.00
CHEMBL1973516 — Ki = 100.0 nM 7.00
CHEMBL1825138 — Ki = 100.0 nM 7.00
CHEMBL1983111 — Ki = 100.0 nM 7.00
CHEMBL2005631 — Ki = 100.0 nM 7.00
CHEMBL2001751 — Ki = 125.89 nM 6.90
CHEMBL1999414 — Ki = 125.89 nM 6.90
CHEMBL1997924 — Ki = 125.89 nM 6.90
CHEMBL1979577 — Ki = 125.89 nM 6.90
CHEMBL1988838 — Ki = 158.49 nM 6.80
CHEMBL1999484 — Ki = 158.49 nM 6.80
CHEMBL2004716 — Ki = 158.49 nM 6.80
CHEMBL2001257 — Ki = 158.49 nM 6.80
CHEMBL2000335 — Ki = 158.49 nM 6.80
CHEMBL509032 TAE-684 Ki = 158.49 nM 6.80
CHEMBL1988163 — Ki = 158.49 nM 6.80
CHEMBL1989043 — Ki = 199.53 nM 6.70
CHEMBL1979883 — Ki = 199.53 nM 6.70
CHEMBL1973211 — Ki = 199.53 nM 6.70
CHEMBL1964692 — Ki = 199.53 nM 6.70
CHEMBL1989708 — Ki = 199.53 nM 6.70
CHEMBL1084546 PF-00562271 Ki = 199.53 nM 6.70
CHEMBL1825138 — Ki = 199.53 nM 6.70
CHEMBL1980407 — Ki = 251.19 nM 6.60
CHEMBL1090360 — Ki = 251.19 nM 6.60
CHEMBL243088 — Ki = 251.19 nM 6.60
CHEMBL1969483 — Ki = 251.19 nM 6.60
CHEMBL1241473 — Ki = 251.19 nM 6.60
CHEMBL1998585 — Ki = 251.19 nM 6.60