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Assay Detail

CHEMBL1963777

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ACK1
ChEMBL ↗
327
Total Activities
317
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Activated CDC42 kinase 1 (CHEMBL4599) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 327 6.06 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL509032 TAE-684 — 1 9.10
CHEMBL49120 PD-0166285 1.0 1 8.90
CHEMBL1980995 — — 1 8.80
CHEMBL5416410 DASATINIB 4.0 1 8.60
CHEMBL1993661 — — 1 8.40
CHEMBL1980297 ILORASERTIB 2.0 1 8.10
CHEMBL1965170 — — 1 7.90
CHEMBL1972220 — — 1 7.80
CHEMBL1164180 — — 1 7.60
CHEMBL1967878 CENISERTIB 2.0 1 7.60
CHEMBL2007421 — — 1 7.60
CHEMBL1989708 — — 1 7.50
CHEMBL1983268 ENTRECTINIB 4.0 1 7.50
CHEMBL458997 — — 1 7.40
CHEMBL1988581 — — 1 7.20
CHEMBL1983111 — — 1 7.20
CHEMBL1979690 — — 1 7.20
CHEMBL1967998 — — 1 7.20
CHEMBL2002099 — — 2 7.10
CHEMBL2006564 — — 1 7.10
CHEMBL1973516 — — 2 7.00
CHEMBL1977138 — — 1 7.00
CHEMBL1981047 — — 1 7.00
CHEMBL202721 — — 1 6.90
CHEMBL21156 — — 1 6.90
CHEMBL475251 R-406 2.0 1 6.90
CHEMBL2004290 — — 1 6.90
CHEMBL1989267 — — 1 6.80
CHEMBL482967 CYC-116 1.0 1 6.80
CHEMBL1999484 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL509032 TAE-684 Ki = 0.7943 nM 9.10
CHEMBL49120 PD-0166285 Ki = 1.259 nM 8.90
CHEMBL1980995 — Ki = 1.585 nM 8.80
CHEMBL5416410 DASATINIB Ki = 2.512 nM 8.60
CHEMBL1993661 — Ki = 3.981 nM 8.40
CHEMBL1980297 ILORASERTIB Ki = 7.943 nM 8.10
CHEMBL1965170 — Ki = 12.59 nM 7.90
CHEMBL1972220 — Ki = 15.85 nM 7.80
CHEMBL1164180 — Ki = 25.12 nM 7.60
CHEMBL1967878 CENISERTIB Ki = 25.12 nM 7.60
CHEMBL2007421 — Ki = 25.12 nM 7.60
CHEMBL1983268 ENTRECTINIB Ki = 31.62 nM 7.50
CHEMBL1989708 — Ki = 31.62 nM 7.50
CHEMBL458997 — Ki = 39.81 nM 7.40
CHEMBL1967998 — Ki = 63.1 nM 7.20
CHEMBL1988581 — Ki = 63.1 nM 7.20
CHEMBL1979690 — Ki = 63.1 nM 7.20
CHEMBL1983111 — Ki = 63.1 nM 7.20
CHEMBL2006564 — Ki = 79.43 nM 7.10
CHEMBL2002099 — Ki = 79.43 nM 7.10
CHEMBL1977138 — Ki = 100.0 nM 7.00
CHEMBL1981047 — Ki = 100.0 nM 7.00
CHEMBL1973516 — Ki = 100.0 nM 7.00
CHEMBL475251 R-406 Ki = 125.89 nM 6.90
CHEMBL21156 — Ki = 125.89 nM 6.90
CHEMBL202721 — Ki = 125.89 nM 6.90
CHEMBL2004290 — Ki = 125.89 nM 6.90
CHEMBL482967 CYC-116 Ki = 158.49 nM 6.80
CHEMBL1999484 — Ki = 158.49 nM 6.80
CHEMBL1989267 — Ki = 158.49 nM 6.80
CHEMBL1977134 — Ki = 199.53 nM 6.70
CHEMBL2006765 — Ki = 199.53 nM 6.70
CHEMBL2002099 — Ki = 199.53 nM 6.70
CHEMBL101311 — Ki = 251.19 nM 6.60
CHEMBL1973359 — Ki = 251.19 nM 6.60
CHEMBL1983715 — Ki = 251.19 nM 6.60
CHEMBL1978166 — Ki = 316.23 nM 6.50
CHEMBL1976376 — Ki = 316.23 nM 6.50
CHEMBL1978166 — Ki = 316.23 nM 6.50
CHEMBL1976420 — Ki = 316.23 nM 6.50
CHEMBL1972462 — Ki = 316.23 nM 6.50
CHEMBL1973516 — Ki = 398.11 nM 6.40
CHEMBL1988692 — Ki = 398.11 nM 6.40
CHEMBL1825138 — Ki = 398.11 nM 6.40
CHEMBL1975927 — Ki = 398.11 nM 6.40
CHEMBL1081312 — Ki = 398.11 nM 6.40
CHEMBL1976040 ADAVOSERTIB Ki = 501.19 nM 6.30
CHEMBL1966501 — Ki = 501.19 nM 6.30
CHEMBL1992581 — Ki = 501.19 nM 6.30
CHEMBL1988141 — Ki = 630.96 nM 6.20