Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1963780

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ERBB2
ChEMBL ↗
583
Total Activities
576
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 583 6.70 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1999749 — — 1 8.80
CHEMBL554 LAPATINIB 4.0 2 8.80
CHEMBL1991429 — — 1 8.40
CHEMBL2006715 — — 1 8.40
CHEMBL1090360 — — 1 8.20
CHEMBL1981725 — — 1 8.00
CHEMBL1997617 — — 1 7.90
CHEMBL553 ERLOTINIB 4.0 1 7.70
CHEMBL939 GEFITINIB 4.0 2 7.60
CHEMBL1980995 — — 1 7.50
CHEMBL1978448 — — 1 7.50
CHEMBL475251 R-406 2.0 1 7.50
CHEMBL539474 — — 1 7.40
CHEMBL509032 TAE-684 — 1 7.40
CHEMBL1970879 — — 1 7.30
CHEMBL458997 — — 1 7.20
CHEMBL1090356 — — 1 7.10
CHEMBL1972584 — — 2 6.90
CHEMBL1982476 — — 1 6.90
CHEMBL1967878 CENISERTIB 2.0 1 6.90
CHEMBL5416410 DASATINIB 4.0 1 6.80
CHEMBL1993661 — — 1 6.80
CHEMBL1987034 — — 1 6.70
CHEMBL1682558 — — 1 6.60
CHEMBL1971029 — — 1 6.60
CHEMBL302449 GO-6976 — 1 6.60
CHEMBL1971943 BAY-549 — 1 6.50
CHEMBL1982980 — — 1 6.50
CHEMBL1980163 — — 1 6.50
CHEMBL2006276 — — 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL554 LAPATINIB Ki = 1.585 nM 8.80
CHEMBL554 LAPATINIB Ki = 1.585 nM 8.80
CHEMBL1999749 — Ki = 1.585 nM 8.80
CHEMBL2006715 — Ki = 3.981 nM 8.40
CHEMBL1991429 — Ki = 3.981 nM 8.40
CHEMBL1090360 — Ki = 6.31 nM 8.20
CHEMBL1981725 — Ki = 10.0 nM 8.00
CHEMBL1997617 — Ki = 12.59 nM 7.90
CHEMBL553 ERLOTINIB Ki = 19.95 nM 7.70
CHEMBL939 GEFITINIB Ki = 25.12 nM 7.60
CHEMBL939 GEFITINIB Ki = 25.12 nM 7.60
CHEMBL1978448 — Ki = 31.62 nM 7.50
CHEMBL475251 R-406 Ki = 31.62 nM 7.50
CHEMBL1980995 — Ki = 31.62 nM 7.50
CHEMBL509032 TAE-684 Ki = 39.81 nM 7.40
CHEMBL539474 — Ki = 39.81 nM 7.40
CHEMBL1970879 — Ki = 50.12 nM 7.30
CHEMBL458997 — Ki = 63.1 nM 7.20
CHEMBL1090356 — Ki = 79.43 nM 7.10
CHEMBL1967878 CENISERTIB Ki = 125.89 nM 6.90
CHEMBL1972584 — Ki = 125.89 nM 6.90
CHEMBL1982476 — Ki = 125.89 nM 6.90
CHEMBL1972584 — Ki = 125.89 nM 6.90
CHEMBL5416410 DASATINIB Ki = 158.49 nM 6.80
CHEMBL1993661 — Ki = 158.49 nM 6.80
CHEMBL1987034 — Ki = 199.53 nM 6.70
CHEMBL1682558 — Ki = 251.19 nM 6.60
CHEMBL302449 GO-6976 Ki = 251.19 nM 6.60
CHEMBL1971029 — Ki = 251.19 nM 6.60
CHEMBL1982980 — Ki = 316.23 nM 6.50
CHEMBL1980163 — Ki = 316.23 nM 6.50
CHEMBL1971943 BAY-549 Ki = 316.23 nM 6.50
CHEMBL2006276 — Ki = 316.23 nM 6.50
CHEMBL1965423 — Ki = 398.11 nM 6.40
CHEMBL1999590 — Ki = 398.11 nM 6.40
CHEMBL491473 CEDIRANIB Ki = 398.11 nM 6.40
CHEMBL1996066 — Ki = 398.11 nM 6.40
CHEMBL2004419 — Ki = 501.19 nM 6.30
CHEMBL1980297 ILORASERTIB Ki = 501.19 nM 6.30
CHEMBL2003657 — Ki = 630.96 nM 6.20
CHEMBL306380 — Ki = 630.96 nM 6.20
CHEMBL326282 — Ki = 630.96 nM 6.20
CHEMBL2003768 — Ki = 794.33 nM 6.10
CHEMBL1988838 — Ki = 794.33 nM 6.10
CHEMBL565612 SOTRASTAURIN Ki = 794.33 nM 6.10
CHEMBL396523 — Ki = 794.33 nM 6.10
CHEMBL2001751 — Ki = 1000.0 nM 6.00
CHEMBL2006778 — Ki = 1000.0 nM 6.00
CHEMBL1985095 — Ki = 1000.0 nM 6.00
CHEMBL1976732 — Ki = 1000.0 nM 6.00