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Assay Detail

CHEMBL1963803

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PTK6
ChEMBL ↗
403
Total Activities
398
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein-tyrosine kinase 6 (CHEMBL4601) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 403 6.64 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1997617 — — 1 8.50
CHEMBL5416410 DASATINIB 4.0 1 8.30
CHEMBL306380 — — 1 8.10
CHEMBL509032 TAE-684 — 1 7.90
CHEMBL1981725 — — 1 7.90
CHEMBL1972584 — — 2 7.90
CHEMBL1982660 — — 2 7.80
CHEMBL1994938 — — 1 7.80
CHEMBL1983932 — — 1 7.80
CHEMBL1998112 — — 1 7.50
CHEMBL491473 CEDIRANIB 3.0 1 7.40
CHEMBL458997 — — 1 7.30
CHEMBL1996979 — — 1 7.10
CHEMBL1993661 — — 1 7.10
CHEMBL1090356 — — 1 7.00
CHEMBL1993243 — — 1 6.90
CHEMBL1987034 — — 1 6.70
CHEMBL1988717 — — 1 6.50
CHEMBL1989708 — — 1 6.50
CHEMBL1976420 — — 1 6.50
CHEMBL253969 OSI-632 2.0 1 6.50
CHEMBL1971029 — — 1 6.40
CHEMBL1981047 — — 1 6.40
CHEMBL1964444 — — 1 6.40
CHEMBL1992306 — — 1 6.30
CHEMBL1965570 — — 1 6.30
CHEMBL508928 — — 1 6.30
CHEMBL1969502 — — 1 6.30
CHEMBL475251 R-406 2.0 1 6.20
CHEMBL1968791 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1997617 — Ki = 3.162 nM 8.50
CHEMBL5416410 DASATINIB Ki = 5.012 nM 8.30
CHEMBL306380 — Ki = 7.943 nM 8.10
CHEMBL509032 TAE-684 Ki = 12.59 nM 7.90
CHEMBL1972584 — Ki = 12.59 nM 7.90
CHEMBL1981725 — Ki = 12.59 nM 7.90
CHEMBL1972584 — Ki = 12.59 nM 7.90
CHEMBL1994938 — Ki = 15.85 nM 7.80
CHEMBL1982660 — Ki = 15.85 nM 7.80
CHEMBL1982660 — Ki = 15.85 nM 7.80
CHEMBL1983932 — Ki = 15.85 nM 7.80
CHEMBL1998112 — Ki = 31.62 nM 7.50
CHEMBL491473 CEDIRANIB Ki = 39.81 nM 7.40
CHEMBL458997 — Ki = 50.12 nM 7.30
CHEMBL1996979 — Ki = 79.43 nM 7.10
CHEMBL1993661 — Ki = 79.43 nM 7.10
CHEMBL1090356 — Ki = 100.0 nM 7.00
CHEMBL1993243 — Ki = 125.89 nM 6.90
CHEMBL1987034 — Ki = 199.53 nM 6.70
CHEMBL1988717 — Ki = 316.23 nM 6.50
CHEMBL1976420 — Ki = 316.23 nM 6.50
CHEMBL1989708 — Ki = 316.23 nM 6.50
CHEMBL253969 OSI-632 Ki = 316.23 nM 6.50
CHEMBL1971029 — Ki = 398.11 nM 6.40
CHEMBL1981047 — Ki = 398.11 nM 6.40
CHEMBL1964444 — Ki = 398.11 nM 6.40
CHEMBL1992306 — Ki = 501.19 nM 6.30
CHEMBL1969502 — Ki = 501.19 nM 6.30
CHEMBL1965570 — Ki = 501.19 nM 6.30
CHEMBL508928 — Ki = 501.19 nM 6.30
CHEMBL1983111 — Ki = 630.96 nM 6.20
CHEMBL475251 R-406 Ki = 630.96 nM 6.20
CHEMBL363648 TAK-715 Ki = 630.96 nM 6.20
CHEMBL1969588 — Ki = 630.96 nM 6.20
CHEMBL1968791 — Ki = 630.96 nM 6.20
CHEMBL1964692 — Ki = 794.33 nM 6.10
CHEMBL1991138 — Ki = 794.33 nM 6.10
CHEMBL2002346 — Ki = 794.33 nM 6.10
CHEMBL243088 — Ki = 794.33 nM 6.10
CHEMBL1997764 — Ki = 794.33 nM 6.10
CHEMBL1998585 — Ki = 1000.0 nM 6.00
CHEMBL1998829 — Ki = 1258.93 nM 5.90
CHEMBL1983923 — Ki = 1258.93 nM 5.90
CHEMBL2005886 — Ki = 1584.89 nM 5.80
CHEMBL1978448 — Ki = 1995.26 nM 5.70
CHEMBL2003638 — Ki = 1995.26 nM 5.70
CHEMBL1974328 — Ki = 1995.26 nM 5.70
CHEMBL1974416 — Ki = 1995.26 nM 5.70
CHEMBL316264 — Ki = 1995.26 nM 5.70
CHEMBL1982924 — Ki = 1995.26 nM 5.70