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Assay Detail

CHEMBL1964105

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KIAA1811
ChEMBL ↗
619
Total Activities
609
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase BRSK1 (CHEMBL5650) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 619 5.72 7.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1973540 — — 1 7.90
CHEMBL1967878 CENISERTIB 2.0 1 7.80
CHEMBL1990482 — — 1 7.60
CHEMBL1965507 — — 1 7.50
CHEMBL1997129 — — 1 7.40
CHEMBL1993661 — — 1 7.40
CHEMBL509032 TAE-684 — 1 7.30
CHEMBL1972576 — — 1 7.30
CHEMBL1983111 — — 1 7.10
CHEMBL1988594 — — 1 7.10
CHEMBL1082440 — — 1 7.10
CHEMBL592030 — — 1 7.10
CHEMBL1969502 — — 1 7.10
CHEMBL482967 CYC-116 1.0 1 7.10
CHEMBL248757 — — 1 6.90
CHEMBL1982711 — — 1 6.80
CHEMBL1980144 — — 1 6.80
CHEMBL1990885 — — 1 6.80
CHEMBL2001751 — — 1 6.80
CHEMBL50894 ALSTERPAULLONE — 1 6.80
CHEMBL1988163 — — 1 6.70
CHEMBL1978448 — — 1 6.70
CHEMBL1987007 — — 1 6.70
CHEMBL474432 — — 1 6.60
CHEMBL1988437 — — 1 6.60
CHEMBL514499 GW843682X — 1 6.60
CHEMBL1969523 — — 1 6.50
CHEMBL1993424 — — 1 6.40
CHEMBL522892 DOVITINIB 3.0 1 6.40
CHEMBL1990254 — — 2 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1973540 — Ki = 12.59 nM 7.90
CHEMBL1967878 CENISERTIB Ki = 15.85 nM 7.80
CHEMBL1990482 — Ki = 25.12 nM 7.60
CHEMBL1965507 — Ki = 31.62 nM 7.50
CHEMBL1997129 — Ki = 39.81 nM 7.40
CHEMBL1993661 — Ki = 39.81 nM 7.40
CHEMBL509032 TAE-684 Ki = 50.12 nM 7.30
CHEMBL1972576 — Ki = 50.12 nM 7.30
CHEMBL1988594 — Ki = 79.43 nM 7.10
CHEMBL482967 CYC-116 Ki = 79.43 nM 7.10
CHEMBL1983111 — Ki = 79.43 nM 7.10
CHEMBL1969502 — Ki = 79.43 nM 7.10
CHEMBL592030 — Ki = 79.43 nM 7.10
CHEMBL1082440 — Ki = 79.43 nM 7.10
CHEMBL248757 — Ki = 125.89 nM 6.90
CHEMBL2001751 — Ki = 158.49 nM 6.80
CHEMBL50894 ALSTERPAULLONE Ki = 158.49 nM 6.80
CHEMBL1980144 — Ki = 158.49 nM 6.80
CHEMBL1990885 — Ki = 158.49 nM 6.80
CHEMBL1982711 — Ki = 158.49 nM 6.80
CHEMBL1987007 — Ki = 199.53 nM 6.70
CHEMBL1988163 — Ki = 199.53 nM 6.70
CHEMBL1978448 — Ki = 199.53 nM 6.70
CHEMBL474432 — Ki = 251.19 nM 6.60
CHEMBL514499 GW843682X Ki = 251.19 nM 6.60
CHEMBL1988437 — Ki = 251.19 nM 6.60
CHEMBL1969523 — Ki = 316.23 nM 6.50
CHEMBL223460 — Ki = 398.11 nM 6.40
CHEMBL1990254 — Ki = 398.11 nM 6.40
CHEMBL1993424 — Ki = 398.11 nM 6.40
CHEMBL522892 DOVITINIB Ki = 398.11 nM 6.40
CHEMBL1981047 — Ki = 398.11 nM 6.40
CHEMBL1998121 — Ki = 398.11 nM 6.40
CHEMBL2007064 — Ki = 501.19 nM 6.30
CHEMBL1970203 — Ki = 501.19 nM 6.30
CHEMBL1986263 — Ki = 501.19 nM 6.30
CHEMBL1989646 — Ki = 501.19 nM 6.30
CHEMBL223367 — Ki = 501.19 nM 6.30
CHEMBL1971029 — Ki = 630.96 nM 6.20
CHEMBL1996817 — Ki = 630.96 nM 6.20
CHEMBL1988608 — Ki = 630.96 nM 6.20
CHEMBL1994938 — Ki = 630.96 nM 6.20
CHEMBL1997023 — Ki = 630.96 nM 6.20
CHEMBL2005475 — Ki = 630.96 nM 6.20
CHEMBL1977681 — Ki = 630.96 nM 6.20
CHEMBL1241473 — Ki = 630.96 nM 6.20
CHEMBL1975500 — Ki = 630.96 nM 6.20
CHEMBL244378 — Ki = 630.96 nM 6.20
CHEMBL2002649 — Ki = 630.96 nM 6.20
CHEMBL396523 — Ki = 794.33 nM 6.10