Assay Detail
Binding
CHEMBL2214976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 5.63 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL1644697 | SODIUM CYANIDE | — | 1 | 6.30 |
| CHEMBL1644699 | SODIUM HYDROSULFIDE | — | 1 | 6.22 |
| CHEMBL2207071 | SODIUM FULMINATE | — | 1 | 6.16 |
| CHEMBL89295 | SODIUM AZIDE | — | 1 | 5.92 |
| CHEMBL471245 | SODIUM CARBONOTRITHIOATE | — | 1 | 5.06 |
| CHEMBL232233 | SODIUM SULFAMATE | — | 1 | 4.68 |
| CHEMBL2069541 | SODIUM ISOSELENOCYANATE | — | 1 | 4.07 |
| CHEMBL1644698 | SODIUM NITRATE | 2.0 | 1 | - |
| CHEMBL1200574 | SODIUM CHLORIDE | 4.0 | 1 | - |
| CHEMBL186314 | SODIUM CARBONATE | 4.0 | 1 | - |
| CHEMBL1353 | SODIUM BICARBONATE | 4.0 | 1 | - |
| CHEMBL444819 | SODIUM PERRHENATE | — | 1 | - |
| CHEMBL1081267 | SODIUM PERRUTHENATE | — | 1 | - |
| CHEMBL1644695 | SODIUM IODIDE | 4.0 | 1 | - |
| CHEMBL107217 | DITIOCARB SODIUM | 2.0 | 1 | - |
| CHEMBL233406 | SODIUM SULFATE ANHYDROUS | 4.0 | 1 | - |
| CHEMBL1644700 | SODIUM PERCHLORATE | — | 1 | - |
| CHEMBL1780189 | SODIUM TETRAFLUOROBORATE | — | 1 | - |
| CHEMBL93268 | SODIUM NITRITE | 4.0 | 1 | - |
| CHEMBL2207072 | SODIUM ISOTHIOCYANATE | — | 1 | - |
| CHEMBL1689285 | SODIUM BISULFITE | -1.0 | 1 | - |
| CHEMBL502764 | SODIUM PERSULFATE | — | 1 | - |
| CHEMBL114503 | SODIUM SELENATE | 3.0 | 1 | - |
| CHEMBL471869 | SODIUM TELLURATE | — | 1 | - |
| CHEMBL450079 | SODIUM PYROPHOSPHATE | -1.0 | 1 | - |
| CHEMBL1075630 | SODIUM DIVANADATE | — | 1 | - |
| CHEMBL1528 | SODIUM FLUORIDE | 4.0 | 1 | - |
| CHEMBL1076681 | SODIUM TETRABORATE | — | 1 | - |
| CHEMBL445433 | SODIUM STANNATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1644697 | SODIUM CYANIDE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1644699 | SODIUM HYDROSULFIDE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL2207071 | SODIUM FULMINATE | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL89295 | SODIUM AZIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL471245 | SODIUM CARBONOTRITHIOATE | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL232233 | SODIUM SULFAMATE | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2069541 | SODIUM ISOSELENOCYANATE | Ki | = | 85000.0 | nM | 4.07 |
| CHEMBL444819 | SODIUM PERRHENATE | Ki | = | 110000.0 | nM | - |
| CHEMBL1644694 | SODIUM BROMIDE | Ki | = | 4000000.0 | nM | - |
| CHEMBL1081267 | SODIUM PERRUTHENATE | Ki | = | 101000.0 | nM | - |
| CHEMBL1644695 | SODIUM IODIDE | Ki | = | 300000.0 | nM | - |
| CHEMBL107217 | DITIOCARB SODIUM | Ki | = | 790000.0 | nM | - |
| CHEMBL233406 | SODIUM SULFATE ANHYDROUS | Ki | = | 63000000.0 | nM | - |
| CHEMBL1644700 | SODIUM PERCHLORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL1780189 | SODIUM TETRAFLUOROBORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL1200574 | SODIUM CHLORIDE | Ki | = | 6000000.0 | nM | - |
| CHEMBL450253 | SODIUM FLUOROSULFATE | Ki | = | 790000.0 | nM | - |
| CHEMBL1644701 | SODIUM IMINODISULFATE | Ki | = | 310000.0 | nM | - |
| CHEMBL2206490 | SULFURIC DIAMIDE SODIUM SALT | Ki | = | 310000.0 | nM | - |
| CHEMBL2207070 | PHENYLBORONIC ACID SODIUM SALT | Ki | = | 58600000.0 | nM | - |
| CHEMBL2206489 | PHENYLARSONIC ACID SODIUM SALT | Ki | = | 31700000.0 | nM | - |
| CHEMBL1353 | SODIUM BICARBONATE | Ki | = | 12000000.0 | nM | - |
| CHEMBL186314 | SODIUM CARBONATE | Ki | = | 15000000.0 | nM | - |
| CHEMBL1644698 | SODIUM NITRATE | Ki | = | 7000000.0 | nM | - |
| CHEMBL93268 | SODIUM NITRITE | Ki | = | 8400000.0 | nM | - |
| CHEMBL2207072 | SODIUM ISOTHIOCYANATE | Ki | = | 200000.0 | nM | - |
| CHEMBL1689285 | SODIUM BISULFITE | Ki | = | 18000000.0 | nM | - |
| CHEMBL502764 | SODIUM PERSULFATE | Ki | = | 107000.0 | nM | - |
| CHEMBL114503 | SODIUM SELENATE | Ki | = | 118000000.0 | nM | - |
| CHEMBL471869 | SODIUM TELLURATE | Ki | = | 660000.0 | nM | - |
| CHEMBL450079 | SODIUM PYROPHOSPHATE | Ki | = | 25770000.0 | nM | - |
| CHEMBL1075630 | SODIUM DIVANADATE | Ki | = | 540000.0 | nM | - |
| CHEMBL1528 | SODIUM FLUORIDE | Ki | > | 300000000.0 | nM | - |
| CHEMBL1076681 | SODIUM TETRABORATE | Ki | = | 640000.0 | nM | - |
| CHEMBL445433 | SODIUM STANNATE | Ki | = | 570000.0 | nM | - |