Assay Detail
Functional
CHEMBL3392943
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DNDI: Leish (macro) in Vitro, 96 hour
100
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 4.94 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487366 | — | — | 1 | 6.51 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 6.02 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 5.62 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.58 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 5.04 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.97 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 4.88 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 4.86 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.83 |
| CHEMBL57004 | SITAMAQUINE | 2.0 | 1 | 4.71 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 4.69 |
| CHEMBL3392934 | — | — | 1 | 4.68 |
| CHEMBL251689 | — | — | 1 | 4.55 |
| CHEMBL83668 | TOLNAFTATE | 3.0 | 1 | 4.30 |
| CHEMBL282121 | MEBEVERINE | 3.0 | 1 | 4.26 |
| CHEMBL1592316 | — | — | 1 | 4.26 |
| CHEMBL822 | TERBINAFINE | 4.0 | 1 | 4.16 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | - |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | - |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | - |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | - |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | - |
| CHEMBL1479 | DANAZOL | 4.0 | 1 | - |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | - |
| CHEMBL296480 | — | — | 1 | - |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | - |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | - |
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | - |
| CHEMBL183041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487366 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 9090.0 | nM | 5.04 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 10790.0 | nM | 4.97 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 13970.0 | nM | 4.86 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 14670.0 | nM | 4.83 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 19480.0 | nM | 4.71 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 20250.0 | nM | 4.69 |
| CHEMBL3392934 | — | IC50 | = | 20680.0 | nM | 4.68 |
| CHEMBL251689 | — | IC50 | = | 28190.0 | nM | 4.55 |
| CHEMBL83668 | TOLNAFTATE | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL1592316 | — | IC50 | = | 54360.0 | nM | 4.26 |
| CHEMBL282121 | MEBEVERINE | IC50 | = | 54940.0 | nM | 4.26 |
| CHEMBL822 | TERBINAFINE | IC50 | = | 69540.0 | nM | 4.16 |
| CHEMBL436921 | — | IC50 | > | 22500.0 | nM | - |
| CHEMBL439 | SULFADIAZINE | IC50 | > | 12040.0 | nM | - |
| CHEMBL3392931 | — | IC50 | > | 39900.0 | nM | - |
| CHEMBL1237057 | — | IC50 | > | 21090.0 | nM | - |
| CHEMBL1140 | NIACINAMIDE | IC50 | > | 245650.0 | nM | - |
| CHEMBL3392932 | — | IC50 | > | 73790.0 | nM | - |
| CHEMBL3039774 | — | IC50 | > | 7800.0 | nM | - |
| CHEMBL3392933 | — | IC50 | > | 2160.0 | nM | - |
| CHEMBL2105542 | SATRANIDAZOLE | IC50 | > | 103710.0 | nM | - |
| CHEMBL498847 | SECNIDAZOLE | IC50 | > | 161120.0 | nM | - |
| CHEMBL1449676 | ORNIDAZOLE | IC50 | > | 135970.0 | nM | - |
| CHEMBL3392935 | — | IC50 | > | 167310.0 | nM | - |
| CHEMBL3392936 | — | IC50 | > | 30070.0 | nM | - |
| CHEMBL1257030 | LONIDAMINE | IC50 | > | 93410.0 | nM | - |
| CHEMBL415087 | CLOPERASTINE | IC50 | > | 30310.0 | nM | - |
| CHEMBL415 | CLOMIPRAMINE | IC50 | > | 9530.0 | nM | - |
| CHEMBL157101 | KETOCONAZOLE | IC50 | > | 18820.0 | nM | - |
| CHEMBL116 | AMPRENAVIR | IC50 | > | 59330.0 | nM | - |
| CHEMBL991 | STAVUDINE | IC50 | > | 133800.0 | nM | - |
| CHEMBL106 | FLUCONAZOLE | IC50 | > | 97950.0 | nM | - |
| CHEMBL729 | LOPINAVIR | IC50 | > | 47710.0 | nM | - |
| CHEMBL1479 | DANAZOL | IC50 | > | 29630.0 | nM | - |
| CHEMBL1323 | DARUNAVIR | IC50 | > | 54780.0 | nM | - |
| CHEMBL296480 | — | IC50 | > | 44720.0 | nM | - |
| CHEMBL1163 | ATAZANAVIR | IC50 | > | 37460.0 | nM | - |
| CHEMBL137 | METRONIDAZOLE | IC50 | > | 175280.0 | nM | - |
| CHEMBL779 | TADALAFIL | IC50 | > | 77040.0 | nM | - |
| CHEMBL534 | KETOTIFEN | IC50 | > | 96950.0 | nM | - |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | > | 7740.0 | nM | - |
| CHEMBL183041 | — | IC50 | > | 49780.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 117540.0 | nM | - |
| CHEMBL1366 | AURANOFIN | IC50 | > | 1470.0 | nM | - |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | > | 59450.0 | nM | - |