Assay Detail
Binding
CHEMBL4044725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 4.96 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL471245 | SODIUM CARBONOTRITHIOATE | — | 1 | 5.06 |
| CHEMBL1644697 | SODIUM CYANIDE | — | 1 | 4.70 |
| CHEMBL1644696 | SODIUM CYANATE | — | 1 | 4.52 |
| CHEMBL1644699 | SODIUM HYDROSULFIDE | — | 1 | 4.40 |
| CHEMBL502764 | SODIUM PERSULFATE | — | 1 | 4.08 |
| CHEMBL2069541 | SODIUM ISOSELENOCYANATE | — | 1 | 4.07 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
| CHEMBL1644698 | SODIUM NITRATE | 2.0 | 1 | - |
| CHEMBL364571 | PHENYLARSONIC ACID | — | 1 | - |
| CHEMBL93268 | SODIUM NITRITE | 4.0 | 1 | - |
| CHEMBL1200574 | SODIUM CHLORIDE | 4.0 | 1 | - |
| CHEMBL1644694 | SODIUM BROMIDE | 3.0 | 1 | - |
| CHEMBL1644695 | SODIUM IODIDE | 4.0 | 1 | - |
| CHEMBL2207072 | SODIUM ISOTHIOCYANATE | — | 1 | - |
| CHEMBL89295 | SODIUM AZIDE | — | 1 | - |
| CHEMBL1353 | SODIUM BICARBONATE | 4.0 | 1 | - |
| CHEMBL186314 | SODIUM CARBONATE | 4.0 | 1 | - |
| CHEMBL68253 | SULFAMATE | — | 1 | - |
| CHEMBL355001 | SULFAMIDE | — | 1 | - |
| CHEMBL471244 | SODIUM IMINODISULFONATE | — | 1 | - |
| CHEMBL3326865 | — | — | 1 | - |
| CHEMBL3327018 | — | — | 1 | - |
| CHEMBL450253 | SODIUM FLUOROSULFATE | — | 1 | - |
| CHEMBL1780189 | SODIUM TETRAFLUOROBORATE | — | 1 | - |
| CHEMBL1644700 | SODIUM PERCHLORATE | — | 1 | - |
| CHEMBL107217 | DITIOCARB SODIUM | 2.0 | 1 | - |
| CHEMBL4094043 | — | — | 1 | - |
| CHEMBL1075630 | SODIUM DIVANADATE | — | 1 | - |
| CHEMBL444819 | SODIUM PERRHENATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL471245 | SODIUM CARBONOTRITHIOATE | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL1644697 | SODIUM CYANIDE | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL1644696 | SODIUM CYANATE | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL1644699 | SODIUM HYDROSULFIDE | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL502764 | SODIUM PERSULFATE | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL2069541 | SODIUM ISOSELENOCYANATE | Ki | = | 86000.0 | nM | 4.07 |
| CHEMBL1644694 | SODIUM BROMIDE | Ki | = | 63000000.0 | nM | - |
| CHEMBL1528 | SODIUM FLUORIDE | Ki | > | 300000000.0 | nM | - |
| CHEMBL1644695 | SODIUM IODIDE | Ki | = | 26000000.0 | nM | - |
| CHEMBL2207072 | SODIUM ISOTHIOCYANATE | Ki | = | 1600000.0 | nM | - |
| CHEMBL89295 | SODIUM AZIDE | Ki | = | 1500000.0 | nM | - |
| CHEMBL1353 | SODIUM BICARBONATE | Ki | = | 85000000.0 | nM | - |
| CHEMBL186314 | SODIUM CARBONATE | Ki | = | 73000000.0 | nM | - |
| CHEMBL1644698 | SODIUM NITRATE | Ki | = | 35000000.0 | nM | - |
| CHEMBL1076681 | SODIUM TETRABORATE | Ki | = | 950000.0 | nM | - |
| CHEMBL1689285 | SODIUM BISULFITE | Ki | = | 89000000.0 | nM | - |
| CHEMBL233406 | SODIUM SULFATE ANHYDROUS | Ki | > | 200000000.0 | nM | - |
| CHEMBL445433 | SODIUM STANNATE | Ki | = | 830000.0 | nM | - |
| CHEMBL114503 | SODIUM SELENATE | Ki | = | 112000000.0 | nM | - |
| CHEMBL471869 | SODIUM TELLURATE | Ki | = | 920000.0 | nM | - |
| CHEMBL450079 | SODIUM PYROPHOSPHATE | Ki | = | 48500000.0 | nM | - |
| CHEMBL1200574 | SODIUM CHLORIDE | Ki | = | 200000000.0 | nM | - |
| CHEMBL93268 | SODIUM NITRITE | Ki | = | 63000000.0 | nM | - |
| CHEMBL364571 | PHENYLARSONIC ACID | Ki | = | 49200000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 23100000.0 | nM | - |
| CHEMBL68253 | SULFAMATE | Ki | = | 390000.0 | nM | - |
| CHEMBL355001 | SULFAMIDE | Ki | = | 1130000.0 | nM | - |
| CHEMBL471244 | SODIUM IMINODISULFONATE | Ki | = | 760000.0 | nM | - |
| CHEMBL3326865 | — | Ki | - | — | - | |
| CHEMBL3327018 | — | Ki | - | — | - | |
| CHEMBL450253 | SODIUM FLUOROSULFATE | Ki | = | 460000.0 | nM | - |
| CHEMBL1780189 | SODIUM TETRAFLUOROBORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL1644700 | SODIUM PERCHLORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL107217 | DITIOCARB SODIUM | Ki | = | 3100000.0 | nM | - |
| CHEMBL4094043 | — | Ki | = | 690000.0 | nM | - |
| CHEMBL1075630 | SODIUM DIVANADATE | Ki | = | 570000.0 | nM | - |
| CHEMBL444819 | SODIUM PERRHENATE | Ki | = | 750000.0 | nM | - |