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Compound Detail

CHEMBL1359321

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CCOC(=O)c1cnc(-n2nc(C)cc2C)nc1NC(C)c1ccccc1

Basic Information

ChEMBL ID CHEMBL1359321
Phase Preclinical
Structure Type MOL
InChI Key YYXJFGVZHAYZCA-UHFFFAOYSA-N
5
Targets
6
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

365.4
MW (Da)
3.63
ALogP
7
HBA
1
HBD
81.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H23N5O2
MW 365.44
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.99

Activity Summary

EC50 4 meas. best 5.84
IC50 2 meas. best 5.98

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.98 5.98 1058.0 1
Unchecked
CHEMBL612545
EC50 5.84 5.84 1458.0 1
Streptokinase A
CHEMBL1293228
EC50 5.56 5.56 2743.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.3 5.3 5037.0 1
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
CHEMBL2164
IC50 5.23 5.23 5878.0 1
Streptococcus
CHEMBL612313
EC50 5.23 5.23 5891.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine