Compound Detail
CHEMBL13828
OXATOMIDE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL13828 |
| Name | OXATOMIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | BAINIUMDFURPJM-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
8
Targets
19
Activities
4
Assay Types
0
PK Parameters
20
Publications
9
Known Names
2
Indications
1
Mechanisms
Molecular Properties
426.6
MW (Da)
4.13
ALogP
4
HBA
1
HBD
44.3
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Histamine H1 receptor antagonist | ANTAGONIST | Histamine H1 receptor | ✓ | ✓ |
Indications
Hypersensitivity Muscular Dystrophy, Duchenne
ATC Classification
R06AE06
oxatomide
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
Activity Summary
IC50 11 meas. best 8.05
EC50 6 meas. best 6.4
Kd 1 meas. best 7.34
Ki 1 meas. best 7.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL3943 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Cavia porcellus CHEMBL369 | Kd | 7.34 | 7.34 | 45.7 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 7.2 | 7.2 | 62.7 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 6.4 | 5.466 | 400.0 | 5 |
| P2X purinoceptor 7 CHEMBL4805 | IC50 | 6.08 | 6.08 | 830.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.4 | 5.0286 | 3981.1 | 7 |
| Unchecked CHEMBL612545 | IC50 | 4.77 | 4.77 | 17139.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 4.7 | 4.7 | 20100.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL2146315 | EC50 | 4.6 | 4.6 | 25100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine