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Compound Detail

CHEMBL1428153

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Cc1cccc(NC2=Nc3ccccc3N3C2=Nc2c(c(C)nn2-c2ccccc2)C3c2ccc(O)c(O)c2)c1

Basic Information

ChEMBL ID CHEMBL1428153
Phase Preclinical
Structure Type MOL
InChI Key VDXQGNUWBUFDMK-UHFFFAOYSA-N
6
Targets
7
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

526.6
MW (Da)
6.70
ALogP
8
HBA
3
HBD
98.3
PSA (Ų)
0.23
QED
2
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H26N6O2
MW 526.60
Aromatic Rings 5
Heavy Atoms 40
NP-Likeness -1.04

Activity Summary

EC50 5 meas. best 5.81
IC50 2 meas. best 5.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.81 5.81 1537.0 1
Streptococcus
CHEMBL612313
EC50 5.5 5.5 3198.0 1
Sphingosine 1-phosphate receptor 2
CHEMBL2955
IC50 5.36 5.23 4374.0 2
Streptokinase A
CHEMBL1293228
EC50 5.34 5.34 4537.0 1
Zinc finger protein mex-5
CHEMBL1293319
EC50 4.55 4.55 28257.0 1
RNA-binding protein pos-1
CHEMBL1293304
EC50 4.33 4.33 46434.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine