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Compound Detail

CHEMBL1568474

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Cc1ccc(N=Nc2c(O)ccc3[nH]nnc23)cc1

Basic Information

ChEMBL ID CHEMBL1568474
Phase Preclinical
Structure Type MOL
InChI Key LYJIGLUCSHCFJC-UHFFFAOYSA-N
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

253.3
MW (Da)
3.39
ALogP
5
HBA
2
HBD
86.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H11N5O
MW 253.26
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness -0.99

Activity Summary

EC50 7 meas. best 6.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.4 5.35 399.0 2
HEK293
CHEMBL614818
EC50 6.18 6.18 658.6 1
Insulin-degrading enzyme
CHEMBL1293287
EC50 6.05 5.965 891.5 2
Zinc finger protein mex-5
CHEMBL1293319
EC50 5.53 5.53 2988.0 1
RNA-binding protein pos-1
CHEMBL1293304
EC50 4.65 4.65 22443.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine