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Compound Detail

CHEMBL5184953

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CNC(=O)c1cc(-c2cnc3cc(-c4cnn(C)c4)c(O[C@H]4CCOC4)nn23)c(F)c(C(F)F)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5184953
Phase Preclinical
Structure Type MOL
InChI Key VSDZEHDPNRWKLG-AWEZNQCLSA-N
7
Targets
9
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

486.4
MW (Da)
3.40
ALogP
8
HBA
1
HBD
95.6
PSA (Ų)
0.45
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H21F3N6O3
MW 486.45
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -1.41

Activity Summary

IC50 9 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fibroblast growth factor receptor 3
CHEMBL2742
 IC50 9.05 8.8967 0.9 3
Fibroblast growth factor receptor 3
CHEMBL4066
 IC50 7.89 7.89 13.0 1
Fibroblast growth factor receptor 1
CHEMBL3650
 IC50 7.31 7.31 49.0 1
Receptor-type tyrosine-protein kinase FLT3
CHEMBL1974
 IC50 7.01 7.01 98.0 1
High affinity nerve growth factor receptor
CHEMBL2815
 IC50 6.35 6.35 443.0 1
Mast/stem cell growth factor receptor Kit
CHEMBL1936
 IC50 6.21 6.21 619.0 1
Platelet-derived growth factor receptor beta
CHEMBL1913
 IC50 6.1 6.1 800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Fibroblast growth factor receptor 3 IC50 = 0.9 nM 9.05 Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 resi... 36356320
Fibroblast growth factor receptor 3 IC50 = 0.9 nM 9.05 Inhibition of recombinant human FGFR3 V555M mutant using biotin-EQEDEPEGDYFEWLE-... 36356320
Fibroblast growth factor receptor 3 IC50 = 2.6 nM 8.59 Inhibition of recombinant human FGFR3 V555L mutant using biotin-EQEDEPEGDYFEWLE-... 36356320
Fibroblast growth factor receptor 3 IC50 = 13.0 nM 7.89 Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate read... 36356320
Fibroblast growth factor receptor 1 IC50 = 49.0 nM 7.31 Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as subs... 36356320
Receptor-type tyrosine-protein kinase FLT3 IC50 = 98.0 nM 7.01 Inhibition of wild type partial length human FLT3 (V592 to Y969 residues) expres... 36356320
High affinity nerve growth factor receptor IC50 = 443.0 nM 6.35 Inhibition of wild type partial length human TRKA (G475 to G790 residues) expres... 36356320
Mast/stem cell growth factor receptor Kit IC50 = 619.0 nM 6.21 Inhibition of wild type partial length human KIT (I571 to D952 residues) express... 36356320
Platelet-derived growth factor receptor beta IC50 = 800.0 nM 6.1 Inhibition of wild type partial length human PDGFRbeta (V582 to Y1009 residues) ... 36356320

Literature References

PubMed DOI Target Context # Activities
36356320 10.1021/acs.jmedchem.2c01366 Fibroblast growth factor receptor 3 4
36356320 10.1021/acs.jmedchem.2c01366 Fibroblast growth factor receptor 1 1
36356320 10.1021/acs.jmedchem.2c01366 Receptor-type tyrosine-protein kinase FLT3 1
36356320 10.1021/acs.jmedchem.2c01366 High affinity nerve growth factor receptor 1
36356320 10.1021/acs.jmedchem.2c01366 Mast/stem cell growth factor receptor Kit 1
36356320 10.1021/acs.jmedchem.2c01366 Platelet-derived growth factor receptor beta 1

Data from ChEMBL 36 via Core Engine