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Assay Detail

CHEMBL1963692

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP2K1
ChEMBL ↗
344
Total Activities
335
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 344 5.84 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1976376 — — 1 8.30
CHEMBL1980995 — — 1 8.20
CHEMBL1983575 — — 1 8.00
CHEMBL1973720 — — 2 7.70
CHEMBL379975 — — 1 7.60
CHEMBL1986943 — — 2 7.50
CHEMBL1991674 — — 1 7.50
CHEMBL1990885 — — 1 7.40
CHEMBL1972220 — — 1 7.30
CHEMBL1967878 CENISERTIB 2.0 1 7.30
CHEMBL49120 PD-0166285 1.0 1 7.30
CHEMBL2006765 — — 1 7.20
CHEMBL1993661 — — 1 7.20
CHEMBL2006564 — — 1 7.10
CHEMBL1988581 — — 1 7.00
CHEMBL1980297 ILORASERTIB 2.0 1 7.00
CHEMBL1983111 — — 1 7.00
CHEMBL21156 — — 1 7.00
CHEMBL1989267 — — 1 6.90
CHEMBL1967998 — — 1 6.90
CHEMBL1979690 — — 1 6.90
CHEMBL522892 DOVITINIB 3.0 1 6.90
CHEMBL202721 — — 1 6.80
CHEMBL2006439 — — 1 6.70
CHEMBL1969151 — — 1 6.70
CHEMBL1983348 — — 1 6.60
CHEMBL1989708 — — 1 6.60
CHEMBL1971519 — — 1 6.60
CHEMBL1997846 — — 1 6.60
CHEMBL406845 — — 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1976376 — Ki = 5.012 nM 8.30
CHEMBL1980995 — Ki = 6.31 nM 8.20
CHEMBL1983575 — Ki = 10.0 nM 8.00
CHEMBL1973720 — Ki = 19.95 nM 7.70
CHEMBL1973720 — Ki = 19.95 nM 7.70
CHEMBL379975 — Ki = 25.12 nM 7.60
CHEMBL1986943 — Ki = 31.62 nM 7.50
CHEMBL1991674 — Ki = 31.62 nM 7.50
CHEMBL1986943 — Ki = 31.62 nM 7.50
CHEMBL1990885 — Ki = 39.81 nM 7.40
CHEMBL1972220 — Ki = 50.12 nM 7.30
CHEMBL49120 PD-0166285 Ki = 50.12 nM 7.30
CHEMBL1967878 CENISERTIB Ki = 50.12 nM 7.30
CHEMBL1993661 — Ki = 63.1 nM 7.20
CHEMBL2006765 — Ki = 63.1 nM 7.20
CHEMBL2006564 — Ki = 79.43 nM 7.10
CHEMBL1983111 — Ki = 100.0 nM 7.00
CHEMBL1988581 — Ki = 100.0 nM 7.00
CHEMBL21156 — Ki = 100.0 nM 7.00
CHEMBL1980297 ILORASERTIB Ki = 100.0 nM 7.00
CHEMBL1979690 — Ki = 125.89 nM 6.90
CHEMBL1967998 — Ki = 125.89 nM 6.90
CHEMBL522892 DOVITINIB Ki = 125.89 nM 6.90
CHEMBL1989267 — Ki = 125.89 nM 6.90
CHEMBL202721 — Ki = 158.49 nM 6.80
CHEMBL2006439 — Ki = 199.53 nM 6.70
CHEMBL1969151 — Ki = 199.53 nM 6.70
CHEMBL1997846 — Ki = 251.19 nM 6.60
CHEMBL1989708 — Ki = 251.19 nM 6.60
CHEMBL1983348 — Ki = 251.19 nM 6.60
CHEMBL1971519 — Ki = 251.19 nM 6.60
CHEMBL406845 — Ki = 251.19 nM 6.60
CHEMBL1998953 — Ki = 316.23 nM 6.50
CHEMBL1980407 — Ki = 316.23 nM 6.50
CHEMBL2005478 — Ki = 398.11 nM 6.40
CHEMBL1982711 — Ki = 398.11 nM 6.40
CHEMBL1081312 — Ki = 398.11 nM 6.40
CHEMBL1983715 — Ki = 398.11 nM 6.40
CHEMBL2007574 — Ki = 398.11 nM 6.40
CHEMBL1993335 — Ki = 398.11 nM 6.40
CHEMBL1988141 — Ki = 398.11 nM 6.40
CHEMBL1978195 — Ki = 501.19 nM 6.30
CHEMBL1974328 — Ki = 501.19 nM 6.30
CHEMBL1992581 — Ki = 501.19 nM 6.30
CHEMBL1983923 — Ki = 501.19 nM 6.30
CHEMBL1978166 — Ki = 501.19 nM 6.30
CHEMBL1978166 — Ki = 501.19 nM 6.30
CHEMBL1993877 — Ki = 501.19 nM 6.30
CHEMBL1973516 — Ki = 630.96 nM 6.20
CHEMBL5416410 DASATINIB Ki = 630.96 nM 6.20