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Assay Detail

CHEMBL1963725

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK8
ChEMBL ↗
930
Total Activities
910
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 8 (CHEMBL2276) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 930 6.09 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL210618 — — 1 8.70
CHEMBL1987034 — — 1 8.60
CHEMBL378627 — — 1 8.50
CHEMBL210963 — — 1 8.50
CHEMBL2004355 — — 1 8.50
CHEMBL377383 — — 1 8.40
CHEMBL210928 — — 1 8.40
CHEMBL242865 — — 1 8.40
CHEMBL424872 — — 1 8.40
CHEMBL243088 — — 1 8.40
CHEMBL244378 — — 1 8.30
CHEMBL396523 — — 1 8.30
CHEMBL1983715 — — 1 8.10
CHEMBL1984206 — — 1 8.10
CHEMBL458997 — — 1 8.10
CHEMBL209534 — — 1 8.10
CHEMBL1241473 — — 1 8.00
CHEMBL21156 — — 1 7.80
CHEMBL1090356 — — 1 7.80
CHEMBL1967878 CENISERTIB 2.0 1 7.50
CHEMBL1999484 — — 1 7.50
CHEMBL1988163 — — 1 7.40
CHEMBL437747 — — 1 7.40
CHEMBL1967998 — — 1 7.40
CHEMBL1993904 — — 1 7.40
CHEMBL1984842 — — 1 7.40
CHEMBL1986781 — — 1 7.40
CHEMBL1979690 — — 1 7.40
CHEMBL2006765 — — 1 7.40
CHEMBL2005792 — — 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL210618 — Ki = 1.995 nM 8.70
CHEMBL1987034 — Ki = 2.512 nM 8.60
CHEMBL2004355 — Ki = 3.162 nM 8.50
CHEMBL210963 — Ki = 3.162 nM 8.50
CHEMBL378627 — Ki = 3.162 nM 8.50
CHEMBL242865 — Ki = 3.981 nM 8.40
CHEMBL377383 — Ki = 3.981 nM 8.40
CHEMBL243088 — Ki = 3.981 nM 8.40
CHEMBL210928 — Ki = 3.981 nM 8.40
CHEMBL424872 — Ki = 3.981 nM 8.40
CHEMBL396523 — Ki = 5.012 nM 8.30
CHEMBL244378 — Ki = 5.012 nM 8.30
CHEMBL458997 — Ki = 7.943 nM 8.10
CHEMBL1983715 — Ki = 7.943 nM 8.10
CHEMBL1984206 — Ki = 7.943 nM 8.10
CHEMBL209534 — Ki = 7.943 nM 8.10
CHEMBL1241473 — Ki = 10.0 nM 8.00
CHEMBL1090356 — Ki = 15.85 nM 7.80
CHEMBL21156 — Ki = 15.85 nM 7.80
CHEMBL1999484 — Ki = 31.62 nM 7.50
CHEMBL1967878 CENISERTIB Ki = 31.62 nM 7.50
CHEMBL1984842 — Ki = 39.81 nM 7.40
CHEMBL2006765 — Ki = 39.81 nM 7.40
CHEMBL1986781 — Ki = 39.81 nM 7.40
CHEMBL1988163 — Ki = 39.81 nM 7.40
CHEMBL1967998 — Ki = 39.81 nM 7.40
CHEMBL1979690 — Ki = 39.81 nM 7.40
CHEMBL437747 — Ki = 39.81 nM 7.40
CHEMBL1993904 — Ki = 39.81 nM 7.40
CHEMBL1984711 — Ki = 50.12 nM 7.30
CHEMBL2005792 — Ki = 50.12 nM 7.30
CHEMBL1997129 — Ki = 63.1 nM 7.20
CHEMBL302449 GO-6976 Ki = 79.43 nM 7.10
CHEMBL482967 CYC-116 Ki = 79.43 nM 7.10
CHEMBL2006564 — Ki = 79.43 nM 7.10
CHEMBL2006567 — Ki = 79.43 nM 7.10
CHEMBL475251 R-406 Ki = 79.43 nM 7.10
CHEMBL1980995 — Ki = 100.0 nM 7.00
CHEMBL1973013 — Ki = 100.0 nM 7.00
CHEMBL1230122 R-1487 Ki = 100.0 nM 7.00
CHEMBL1966628 — Ki = 100.0 nM 7.00
CHEMBL491758 — Ki = 125.89 nM 6.90
CHEMBL2003657 — Ki = 125.89 nM 6.90
CHEMBL1725279 SP-600125 Ki = 125.89 nM 6.90
CHEMBL1973540 — Ki = 125.89 nM 6.90
CHEMBL1985095 — Ki = 125.89 nM 6.90
CHEMBL1975927 — Ki = 125.89 nM 6.90
CHEMBL2000104 — Ki = 125.89 nM 6.90
CHEMBL1993661 — Ki = 125.89 nM 6.90
CHEMBL1991429 — Ki = 125.89 nM 6.90