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Assay Detail

CHEMBL1963737

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PAK1
ChEMBL ↗
754
Total Activities
743
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase PAK 1 (CHEMBL4600) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 754 5.63 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 8.30
CHEMBL1981725 — — 1 7.80
CHEMBL1993661 — — 1 7.50
CHEMBL592030 — — 1 7.20
CHEMBL2000685 — — 1 6.80
CHEMBL1993166 — — 1 6.60
CHEMBL1987034 — — 1 6.50
CHEMBL1241473 — — 1 6.50
CHEMBL1997617 — — 1 6.50
CHEMBL1980391 RG-1530 1.0 1 6.50
CHEMBL2001751 — — 1 6.40
CHEMBL1991728 — — 1 6.40
CHEMBL1090360 — — 1 6.30
CHEMBL590109 — — 1 6.30
CHEMBL1991674 — — 1 6.20
CHEMBL1974870 — — 1 6.20
CHEMBL475251 R-406 2.0 1 6.20
CHEMBL1991063 — — 1 6.10
CHEMBL1966524 — — 1 6.10
CHEMBL1971029 — — 1 6.00
CHEMBL1986943 — — 2 5.90
CHEMBL1970903 — — 1 5.90
CHEMBL1979554 — — 1 5.90
CHEMBL1980715 LAUROGUADINE 2.0 1 5.90
CHEMBL1980297 ILORASERTIB 2.0 1 5.90
CHEMBL1988173 — — 1 5.80
CHEMBL1998121 — — 1 5.80
CHEMBL1997846 — — 1 5.80
CHEMBL437747 — — 1 5.70
CHEMBL1972840 — — 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 5.012 nM 8.30
CHEMBL1981725 — Ki = 15.85 nM 7.80
CHEMBL1993661 — Ki = 31.62 nM 7.50
CHEMBL592030 — Ki = 63.1 nM 7.20
CHEMBL2000685 — Ki = 158.49 nM 6.80
CHEMBL1993166 — Ki = 251.19 nM 6.60
CHEMBL1980391 RG-1530 Ki = 316.23 nM 6.50
CHEMBL1987034 — Ki = 316.23 nM 6.50
CHEMBL1241473 — Ki = 316.23 nM 6.50
CHEMBL1997617 — Ki = 316.23 nM 6.50
CHEMBL2001751 — Ki = 398.11 nM 6.40
CHEMBL1991728 — Ki = 398.11 nM 6.40
CHEMBL590109 — Ki = 501.19 nM 6.30
CHEMBL1090360 — Ki = 501.19 nM 6.30
CHEMBL1974870 — Ki = 630.96 nM 6.20
CHEMBL475251 R-406 Ki = 630.96 nM 6.20
CHEMBL1991674 — Ki = 630.96 nM 6.20
CHEMBL1966524 — Ki = 794.33 nM 6.10
CHEMBL1991063 — Ki = 794.33 nM 6.10
CHEMBL1971029 — Ki = 1000.0 nM 6.00
CHEMBL1980297 ILORASERTIB Ki = 1258.93 nM 5.90
CHEMBL1986943 — Ki = 1258.93 nM 5.90
CHEMBL1970903 — Ki = 1258.93 nM 5.90
CHEMBL1986943 — Ki = 1258.93 nM 5.90
CHEMBL1980715 LAUROGUADINE Ki = 1258.93 nM 5.90
CHEMBL1979554 — Ki = 1258.93 nM 5.90
CHEMBL1988173 — Ki = 1584.89 nM 5.80
CHEMBL1998121 — Ki = 1584.89 nM 5.80
CHEMBL1997846 — Ki = 1584.89 nM 5.80
CHEMBL1973540 — Ki = 1995.26 nM 5.70
CHEMBL1998159 — Ki = 1995.26 nM 5.70
CHEMBL1972840 — Ki = 1995.26 nM 5.70
CHEMBL1977294 — Ki = 1995.26 nM 5.70
CHEMBL437747 — Ki = 1995.26 nM 5.70
CHEMBL1966722 — Ki = 1995.26 nM 5.70
CHEMBL2002165 — Ki = 1995.26 nM 5.70
CHEMBL1983923 — Ki = 2511.89 nM 5.60
CHEMBL1967720 — Ki = 2511.89 nM 5.60
CHEMBL1991180 — Ki = 2511.89 nM 5.60
CHEMBL2005548 — Ki = 2511.89 nM 5.60
CHEMBL1965836 — Ki = 2511.89 nM 5.60
CHEMBL2000335 — Ki = 2511.89 nM 5.60
CHEMBL1996155 — Ki = 3162.28 nM 5.50
CHEMBL1991640 — Ki = 3162.28 nM 5.50
CHEMBL1983255 — Ki = 3162.28 nM 5.50
CHEMBL2005886 — Ki = 3162.28 nM 5.50
CHEMBL1970879 — Ki = 3162.28 nM 5.50
CHEMBL1978448 — Ki = 3162.28 nM 5.50
CHEMBL1967878 CENISERTIB Ki = 3162.28 nM 5.50
CHEMBL1965988 — Ki = 3162.28 nM 5.50