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Assay Detail

CHEMBL1963763

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ZAK
ChEMBL ↗
609
Total Activities
605
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase kinase kinase 20 (CHEMBL3886) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 609 5.71 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1336 SORAFENIB 4.0 1 7.80
CHEMBL1994938 — — 1 7.50
CHEMBL5416410 DASATINIB 4.0 1 7.30
CHEMBL1967116 — — 1 7.00
CHEMBL2006715 — — 1 7.00
CHEMBL1967878 CENISERTIB 2.0 1 7.00
CHEMBL1997129 — — 1 6.80
CHEMBL1992306 — — 1 6.80
CHEMBL1991429 — — 1 6.80
CHEMBL1981725 — — 1 6.80
CHEMBL1969588 — — 1 6.80
CHEMBL1993243 — — 1 6.70
CHEMBL1090360 — — 1 6.70
CHEMBL1973540 — — 1 6.70
CHEMBL2005631 — — 1 6.70
CHEMBL1978448 — — 1 6.60
CHEMBL1987034 — — 1 6.50
CHEMBL497151 — — 1 6.50
CHEMBL1996979 — — 1 6.40
CHEMBL1988717 — — 1 6.40
CHEMBL1725279 SP-600125 — 1 6.30
CHEMBL1988173 — — 1 6.30
CHEMBL1967531 — — 1 6.30
CHEMBL1980297 ILORASERTIB 2.0 1 6.30
CHEMBL1993661 — — 1 6.30
CHEMBL1988163 — — 1 6.20
CHEMBL2004716 — — 1 6.20
CHEMBL371206 — — 1 6.20
CHEMBL1969523 — — 1 6.20
CHEMBL1992634 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1336 SORAFENIB Ki = 15.85 nM 7.80
CHEMBL1994938 — Ki = 31.62 nM 7.50
CHEMBL5416410 DASATINIB Ki = 50.12 nM 7.30
CHEMBL1967116 — Ki = 100.0 nM 7.00
CHEMBL2006715 — Ki = 100.0 nM 7.00
CHEMBL1967878 CENISERTIB Ki = 100.0 nM 7.00
CHEMBL1991429 — Ki = 158.49 nM 6.80
CHEMBL1981725 — Ki = 158.49 nM 6.80
CHEMBL1992306 — Ki = 158.49 nM 6.80
CHEMBL1997129 — Ki = 158.49 nM 6.80
CHEMBL1969588 — Ki = 158.49 nM 6.80
CHEMBL2005631 — Ki = 199.53 nM 6.70
CHEMBL1090360 — Ki = 199.53 nM 6.70
CHEMBL1993243 — Ki = 199.53 nM 6.70
CHEMBL1973540 — Ki = 199.53 nM 6.70
CHEMBL1978448 — Ki = 251.19 nM 6.60
CHEMBL497151 — Ki = 316.23 nM 6.50
CHEMBL1987034 — Ki = 316.23 nM 6.50
CHEMBL1996979 — Ki = 398.11 nM 6.40
CHEMBL1988717 — Ki = 398.11 nM 6.40
CHEMBL1967531 — Ki = 501.19 nM 6.30
CHEMBL1993661 — Ki = 501.19 nM 6.30
CHEMBL1988173 — Ki = 501.19 nM 6.30
CHEMBL1980297 ILORASERTIB Ki = 501.19 nM 6.30
CHEMBL1725279 SP-600125 Ki = 501.19 nM 6.30
CHEMBL2004716 — Ki = 630.96 nM 6.20
CHEMBL1988163 — Ki = 630.96 nM 6.20
CHEMBL1969523 — Ki = 630.96 nM 6.20
CHEMBL371206 — Ki = 630.96 nM 6.20
CHEMBL1992634 — Ki = 630.96 nM 6.20
CHEMBL2000335 — Ki = 794.33 nM 6.10
CHEMBL1990904 — Ki = 794.33 nM 6.10
CHEMBL1976134 — Ki = 794.33 nM 6.10
CHEMBL2003456 — Ki = 794.33 nM 6.10
CHEMBL1988300 — Ki = 794.33 nM 6.10
CHEMBL1983111 — Ki = 794.33 nM 6.10
CHEMBL1974310 — Ki = 794.33 nM 6.10
CHEMBL1994321 — Ki = 794.33 nM 6.10
CHEMBL1964692 — Ki = 794.33 nM 6.10
CHEMBL1994830 — Ki = 794.33 nM 6.10
CHEMBL363648 TAK-715 Ki = 794.33 nM 6.10
CHEMBL2006778 — Ki = 794.33 nM 6.10
CHEMBL1999931 — Ki = 794.33 nM 6.10
CHEMBL1965423 — Ki = 1000.0 nM 6.00
CHEMBL508928 — Ki = 1000.0 nM 6.00
CHEMBL1988153 — Ki = 1000.0 nM 6.00
CHEMBL1988838 — Ki = 1000.0 nM 6.00
CHEMBL2005828 — Ki = 1000.0 nM 6.00
CHEMBL1968590 — Ki = 1258.93 nM 5.90
CHEMBL1988437 — Ki = 1258.93 nM 5.90