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Assay Detail

CHEMBL1963808

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4
ChEMBL ↗
772
Total Activities
758
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 772 5.93 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1993661 — — 1 8.40
CHEMBL1995813 — — 1 8.30
CHEMBL1980995 — — 1 8.00
CHEMBL474432 — — 1 7.90
CHEMBL302449 GO-6976 — 1 7.90
CHEMBL1999279 — — 1 7.80
CHEMBL1996817 — — 1 7.80
CHEMBL1241473 — — 1 7.50
CHEMBL1986943 — — 2 7.40
CHEMBL509032 TAE-684 — 1 7.40
CHEMBL1997554 — — 1 7.40
CHEMBL1966628 — — 1 7.30
CHEMBL1988163 — — 1 7.30
CHEMBL1974328 — — 1 7.30
CHEMBL385478 — — 1 7.30
CHEMBL1975440 — — 1 7.20
CHEMBL1971029 — — 1 7.20
CHEMBL475251 R-406 2.0 1 7.20
CHEMBL210887 — — 1 7.10
CHEMBL1983157 — — 1 7.10
CHEMBL1967878 CENISERTIB 2.0 1 7.10
CHEMBL1969588 — — 1 7.00
CHEMBL1969301 — — 1 7.00
CHEMBL1987034 — — 1 6.90
CHEMBL1991063 — — 1 6.90
CHEMBL1988662 — — 1 6.80
CHEMBL1992922 — — 1 6.80
CHEMBL1725279 SP-600125 — 1 6.80
CHEMBL1983111 — — 1 6.80
CHEMBL2006439 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1993661 — Ki = 3.981 nM 8.40
CHEMBL1995813 — Ki = 5.012 nM 8.30
CHEMBL1980995 — Ki = 10.0 nM 8.00
CHEMBL474432 — Ki = 12.59 nM 7.90
CHEMBL302449 GO-6976 Ki = 12.59 nM 7.90
CHEMBL1999279 — Ki = 15.85 nM 7.80
CHEMBL1996817 — Ki = 15.85 nM 7.80
CHEMBL1241473 — Ki = 31.62 nM 7.50
CHEMBL509032 TAE-684 Ki = 39.81 nM 7.40
CHEMBL1997554 — Ki = 39.81 nM 7.40
CHEMBL1986943 — Ki = 39.81 nM 7.40
CHEMBL1986943 — Ki = 39.81 nM 7.40
CHEMBL1966628 — Ki = 50.12 nM 7.30
CHEMBL385478 — Ki = 50.12 nM 7.30
CHEMBL1988163 — Ki = 50.12 nM 7.30
CHEMBL1974328 — Ki = 50.12 nM 7.30
CHEMBL1975440 — Ki = 63.1 nM 7.20
CHEMBL475251 R-406 Ki = 63.1 nM 7.20
CHEMBL1971029 — Ki = 63.1 nM 7.20
CHEMBL1983157 — Ki = 79.43 nM 7.10
CHEMBL1967878 CENISERTIB Ki = 79.43 nM 7.10
CHEMBL210887 — Ki = 79.43 nM 7.10
CHEMBL1969301 — Ki = 100.0 nM 7.00
CHEMBL1969588 — Ki = 100.0 nM 7.00
CHEMBL1991063 — Ki = 125.89 nM 6.90
CHEMBL1987034 — Ki = 125.89 nM 6.90
CHEMBL1725279 SP-600125 Ki = 158.49 nM 6.80
CHEMBL2006439 — Ki = 158.49 nM 6.80
CHEMBL1974870 — Ki = 158.49 nM 6.80
CHEMBL1516890 GW441756X Ki = 158.49 nM 6.80
CHEMBL1983111 — Ki = 158.49 nM 6.80
CHEMBL1988662 — Ki = 158.49 nM 6.80
CHEMBL1992922 — Ki = 158.49 nM 6.80
CHEMBL1971943 BAY-549 Ki = 199.53 nM 6.70
CHEMBL2000832 — Ki = 199.53 nM 6.70
CHEMBL1986530 — Ki = 199.53 nM 6.70
CHEMBL396523 — Ki = 199.53 nM 6.70
CHEMBL458997 — Ki = 199.53 nM 6.70
CHEMBL1999153 — Ki = 199.53 nM 6.70
CHEMBL2000071 — Ki = 199.53 nM 6.70
CHEMBL1969920 — Ki = 199.53 nM 6.70
CHEMBL2002456 — Ki = 251.19 nM 6.60
CHEMBL2001751 — Ki = 251.19 nM 6.60
CHEMBL1977041 — Ki = 251.19 nM 6.60
CHEMBL482767 SNS-314 Ki = 251.19 nM 6.60
CHEMBL244378 — Ki = 251.19 nM 6.60
CHEMBL1992937 — Ki = 251.19 nM 6.60
CHEMBL1990583 — Ki = 316.23 nM 6.50
CHEMBL1991674 — Ki = 316.23 nM 6.50
CHEMBL1996048 — Ki = 316.23 nM 6.50