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Assay Detail

CHEMBL1963828

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FGFR3
ChEMBL ↗
664
Total Activities
654
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 3 (CHEMBL2742) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 664 6.70 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1993661 — — 1 8.80
CHEMBL2006778 — — 1 8.60
CHEMBL1997924 — — 1 8.50
CHEMBL2005631 — — 1 8.40
CHEMBL1983111 — — 1 8.30
CHEMBL1997822 — — 1 8.30
CHEMBL253969 OSI-632 2.0 1 8.10
CHEMBL1982476 — — 1 8.00
CHEMBL491473 CEDIRANIB 3.0 1 7.90
CHEMBL1973540 — — 1 7.90
CHEMBL1989708 — — 2 7.80
CHEMBL1967116 — — 1 7.80
CHEMBL475251 R-406 2.0 1 7.80
CHEMBL1967878 CENISERTIB 2.0 1 7.70
CHEMBL1980391 RG-1530 1.0 1 7.60
CHEMBL1969102 — — 1 7.60
CHEMBL1997617 — — 1 7.60
CHEMBL1968590 — — 1 7.60
CHEMBL2004716 — — 1 7.60
CHEMBL1981047 — — 1 7.50
CHEMBL1979516 — — 1 7.50
CHEMBL1987034 — — 1 7.40
CHEMBL1980995 — — 1 7.40
CHEMBL1993243 — — 1 7.40
CHEMBL522892 DOVITINIB 3.0 1 7.40
CHEMBL509032 TAE-684 — 1 7.40
CHEMBL1980297 ILORASERTIB 2.0 1 7.40
CHEMBL1988387 — — 1 7.30
CHEMBL1241473 — — 1 7.30
CHEMBL1970083 — — 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1993661 — Ki = 1.585 nM 8.80
CHEMBL2006778 — Ki = 2.512 nM 8.60
CHEMBL1997924 — Ki = 3.162 nM 8.50
CHEMBL2005631 — Ki = 3.981 nM 8.40
CHEMBL1997822 — Ki = 5.012 nM 8.30
CHEMBL1983111 — Ki = 5.012 nM 8.30
CHEMBL253969 OSI-632 Ki = 7.943 nM 8.10
CHEMBL1982476 — Ki = 10.0 nM 8.00
CHEMBL491473 CEDIRANIB Ki = 12.59 nM 7.90
CHEMBL1973540 — Ki = 12.59 nM 7.90
CHEMBL1989708 — Ki = 15.85 nM 7.80
CHEMBL475251 R-406 Ki = 15.85 nM 7.80
CHEMBL1967116 — Ki = 15.85 nM 7.80
CHEMBL1967878 CENISERTIB Ki = 19.95 nM 7.70
CHEMBL1980391 RG-1530 Ki = 25.12 nM 7.60
CHEMBL1969102 — Ki = 25.12 nM 7.60
CHEMBL2004716 — Ki = 25.12 nM 7.60
CHEMBL1968590 — Ki = 25.12 nM 7.60
CHEMBL1997617 — Ki = 25.12 nM 7.60
CHEMBL1981047 — Ki = 31.62 nM 7.50
CHEMBL1979516 — Ki = 31.62 nM 7.50
CHEMBL1980995 — Ki = 39.81 nM 7.40
CHEMBL1989708 — Ki = 39.81 nM 7.40
CHEMBL1980297 ILORASERTIB Ki = 39.81 nM 7.40
CHEMBL509032 TAE-684 Ki = 39.81 nM 7.40
CHEMBL522892 DOVITINIB Ki = 39.81 nM 7.40
CHEMBL1987034 — Ki = 39.81 nM 7.40
CHEMBL1993243 — Ki = 39.81 nM 7.40
CHEMBL1241473 — Ki = 50.12 nM 7.30
CHEMBL1988387 — Ki = 50.12 nM 7.30
CHEMBL1970083 — Ki = 50.12 nM 7.30
CHEMBL1967720 — Ki = 63.1 nM 7.20
CHEMBL1996066 — Ki = 63.1 nM 7.20
CHEMBL2005886 — Ki = 63.1 nM 7.20
CHEMBL1970142 — Ki = 63.1 nM 7.20
CHEMBL1988437 — Ki = 63.1 nM 7.20
CHEMBL1998585 — Ki = 63.1 nM 7.20
CHEMBL1971029 — Ki = 79.43 nM 7.10
CHEMBL1987054 — Ki = 79.43 nM 7.10
CHEMBL1970317 — Ki = 79.43 nM 7.10
CHEMBL1994321 — Ki = 100.0 nM 7.00
CHEMBL1982465 — Ki = 100.0 nM 7.00
CHEMBL1994938 — Ki = 100.0 nM 7.00
CHEMBL1983923 — Ki = 100.0 nM 7.00
CHEMBL482967 CYC-116 Ki = 125.89 nM 6.90
CHEMBL1991078 — Ki = 158.49 nM 6.80
CHEMBL1988838 — Ki = 158.49 nM 6.80
CHEMBL1970104 — Ki = 158.49 nM 6.80
CHEMBL1725279 SP-600125 Ki = 158.49 nM 6.80
CHEMBL1984162 — Ki = 158.49 nM 6.80