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Assay Detail

CHEMBL1963829

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK1
ChEMBL ↗
754
Total Activities
743
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 754 5.94 8.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL474432 — — 1 8.20
CHEMBL2005375 — — 1 8.10
CHEMBL1978448 — — 1 8.00
CHEMBL1241473 — — 1 7.90
CHEMBL1967560 — — 1 7.90
CHEMBL514499 GW843682X — 1 7.90
CHEMBL244378 — — 1 7.50
CHEMBL481491 — — 1 7.40
CHEMBL1993661 — — 1 7.20
CHEMBL565612 SOTRASTAURIN 2.0 1 7.20
CHEMBL539474 — — 1 7.10
CHEMBL396523 — — 1 6.80
CHEMBL458997 — — 1 6.70
CHEMBL1964399 — — 1 6.70
CHEMBL2006263 — — 1 6.70
CHEMBL509032 TAE-684 — 1 6.70
CHEMBL1986943 — — 2 6.60
CHEMBL1996831 — — 1 6.60
CHEMBL1991577 — — 1 6.50
CHEMBL1969523 — — 1 6.50
CHEMBL1971029 — — 1 6.50
CHEMBL2006836 — — 1 6.50
CHEMBL392642 — — 1 6.40
CHEMBL243088 — — 1 6.40
CHEMBL1969537 — — 1 6.40
CHEMBL1988173 — — 1 6.30
CHEMBL2006439 — — 1 6.30
CHEMBL1997846 — — 1 6.30
CHEMBL1997129 — — 1 6.30
CHEMBL2000685 — — 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL474432 — Ki = 6.31 nM 8.20
CHEMBL2005375 — Ki = 7.943 nM 8.10
CHEMBL1978448 — Ki = 10.0 nM 8.00
CHEMBL1967560 — Ki = 12.59 nM 7.90
CHEMBL514499 GW843682X Ki = 12.59 nM 7.90
CHEMBL1241473 — Ki = 12.59 nM 7.90
CHEMBL244378 — Ki = 31.62 nM 7.50
CHEMBL481491 — Ki = 39.81 nM 7.40
CHEMBL1993661 — Ki = 63.1 nM 7.20
CHEMBL565612 SOTRASTAURIN Ki = 63.1 nM 7.20
CHEMBL539474 — Ki = 79.43 nM 7.10
CHEMBL396523 — Ki = 158.49 nM 6.80
CHEMBL1964399 — Ki = 199.53 nM 6.70
CHEMBL509032 TAE-684 Ki = 199.53 nM 6.70
CHEMBL458997 — Ki = 199.53 nM 6.70
CHEMBL2006263 — Ki = 199.53 nM 6.70
CHEMBL1986943 — Ki = 251.19 nM 6.60
CHEMBL1996831 — Ki = 251.19 nM 6.60
CHEMBL1986943 — Ki = 251.19 nM 6.60
CHEMBL1971029 — Ki = 316.23 nM 6.50
CHEMBL1991577 — Ki = 316.23 nM 6.50
CHEMBL2006836 — Ki = 316.23 nM 6.50
CHEMBL1969523 — Ki = 316.23 nM 6.50
CHEMBL392642 — Ki = 398.11 nM 6.40
CHEMBL243088 — Ki = 398.11 nM 6.40
CHEMBL1969537 — Ki = 398.11 nM 6.40
CHEMBL1997846 — Ki = 501.19 nM 6.30
CHEMBL1997129 — Ki = 501.19 nM 6.30
CHEMBL2000685 — Ki = 501.19 nM 6.30
CHEMBL1988173 — Ki = 501.19 nM 6.30
CHEMBL2006439 — Ki = 501.19 nM 6.30
CHEMBL1964777 — Ki = 630.96 nM 6.20
CHEMBL413779 — Ki = 794.33 nM 6.10
CHEMBL1999126 — Ki = 794.33 nM 6.10
CHEMBL1987034 — Ki = 794.33 nM 6.10
CHEMBL2004544 — Ki = 1000.0 nM 6.00
CHEMBL2005936 — Ki = 1000.0 nM 6.00
CHEMBL1989805 — Ki = 1000.0 nM 6.00
CHEMBL223367 — Ki = 1000.0 nM 6.00
CHEMBL1980995 — Ki = 1258.93 nM 5.90
CHEMBL1984274 — Ki = 1258.93 nM 5.90
CHEMBL373598 — Ki = 1258.93 nM 5.90
CHEMBL1999918 — Ki = 1258.93 nM 5.90
CHEMBL1989856 — Ki = 1258.93 nM 5.90
CHEMBL1966722 — Ki = 1584.89 nM 5.80
CHEMBL1970074 — Ki = 1584.89 nM 5.80
CHEMBL1986996 — Ki = 1584.89 nM 5.80
CHEMBL1991640 — Ki = 1584.89 nM 5.80
CHEMBL2002346 — Ki = 1584.89 nM 5.80
CHEMBL1971017 — Ki = 1584.89 nM 5.80