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Assay Detail

CHEMBL1963836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK12
ChEMBL ↗
734
Total Activities
723
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 12 (CHEMBL4674) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 734 5.84 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL225519 — — 1 7.50
CHEMBL244378 — — 1 7.50
CHEMBL1987034 — — 1 7.40
CHEMBL396523 — — 1 7.40
CHEMBL1965660 — — 2 7.10
CHEMBL1977223 — — 1 7.10
CHEMBL475251 R-406 2.0 1 6.90
CHEMBL1986943 — — 2 6.80
CHEMBL1999931 — — 1 6.80
CHEMBL243088 — — 1 6.80
CHEMBL1980995 — — 1 6.70
CHEMBL1969588 — — 1 6.70
CHEMBL2003638 — — 1 6.70
CHEMBL1981079 — — 1 6.60
CHEMBL1997129 — — 1 6.60
CHEMBL1964290 — — 1 6.60
CHEMBL1978448 — — 1 6.50
CHEMBL1998585 — — 1 6.40
CHEMBL422897 — — 1 6.40
CHEMBL1974870 — — 1 6.40
CHEMBL1991063 — — 1 6.40
CHEMBL1995813 — — 1 6.30
CHEMBL1986263 — — 1 6.30
CHEMBL103667 DORAMAPIMOD 2.0 1 6.30
CHEMBL1993661 — — 1 6.30
CHEMBL1991078 — — 1 6.20
CHEMBL1966628 — — 1 6.10
CHEMBL1992732 — — 1 6.10
CHEMBL1988163 — — 1 6.00
CHEMBL437747 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244378 — Ki = 31.62 nM 7.50
CHEMBL225519 — Ki = 31.62 nM 7.50
CHEMBL396523 — Ki = 39.81 nM 7.40
CHEMBL1987034 — Ki = 39.81 nM 7.40
CHEMBL1977223 — Ki = 79.43 nM 7.10
CHEMBL1965660 — Ki = 79.43 nM 7.10
CHEMBL1965660 — Ki = 79.43 nM 7.10
CHEMBL475251 R-406 Ki = 125.89 nM 6.90
CHEMBL243088 — Ki = 158.49 nM 6.80
CHEMBL1986943 — Ki = 158.49 nM 6.80
CHEMBL1999931 — Ki = 158.49 nM 6.80
CHEMBL1986943 — Ki = 158.49 nM 6.80
CHEMBL1969588 — Ki = 199.53 nM 6.70
CHEMBL2003638 — Ki = 199.53 nM 6.70
CHEMBL1980995 — Ki = 199.53 nM 6.70
CHEMBL1997129 — Ki = 251.19 nM 6.60
CHEMBL1964290 — Ki = 251.19 nM 6.60
CHEMBL1981079 — Ki = 251.19 nM 6.60
CHEMBL1978448 — Ki = 316.23 nM 6.50
CHEMBL422897 — Ki = 398.11 nM 6.40
CHEMBL1974870 — Ki = 398.11 nM 6.40
CHEMBL1998585 — Ki = 398.11 nM 6.40
CHEMBL1991063 — Ki = 398.11 nM 6.40
CHEMBL1995813 — Ki = 501.19 nM 6.30
CHEMBL1993661 — Ki = 501.19 nM 6.30
CHEMBL103667 DORAMAPIMOD Ki = 501.19 nM 6.30
CHEMBL1986263 — Ki = 501.19 nM 6.30
CHEMBL1991078 — Ki = 630.96 nM 6.20
CHEMBL1966628 — Ki = 794.33 nM 6.10
CHEMBL1992732 — Ki = 794.33 nM 6.10
CHEMBL1970903 — Ki = 1000.0 nM 6.00
CHEMBL539474 — Ki = 1000.0 nM 6.00
CHEMBL411903 — Ki = 1000.0 nM 6.00
CHEMBL437747 — Ki = 1000.0 nM 6.00
CHEMBL1998159 — Ki = 1000.0 nM 6.00
CHEMBL1988163 — Ki = 1000.0 nM 6.00
CHEMBL1986499 — Ki = 1000.0 nM 6.00
CHEMBL2006715 — Ki = 1258.93 nM 5.90
CHEMBL592030 — Ki = 1258.93 nM 5.90
CHEMBL1965836 — Ki = 1258.93 nM 5.90
CHEMBL1991674 — Ki = 1584.89 nM 5.80
CHEMBL1991640 — Ki = 1584.89 nM 5.80
CHEMBL1983111 — Ki = 1584.89 nM 5.80
CHEMBL1972584 — Ki = 1584.89 nM 5.80
CHEMBL260092 — Ki = 1584.89 nM 5.80
CHEMBL2000832 — Ki = 1584.89 nM 5.80
CHEMBL1241473 — Ki = 1584.89 nM 5.80
CHEMBL1972840 — Ki = 1584.89 nM 5.80
CHEMBL1972584 — Ki = 1584.89 nM 5.80
CHEMBL226471 — Ki = 1995.26 nM 5.70