Compound Detail

CHEMBL1242757

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CC(C)n1nc(-c2cccc3[nH]ccc23)c2c(N)ncnc21

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1242757
Phase	Preclinical
Structure Type	MOL
InChI Key	JSXBAKOSLFZFQZ-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

292.4

MW (Da)

3.14

ALogP

HBA

HBD

85.4

PSA (Å²)

0.59

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C16H16N6
MW	292.35
Aromatic Rings	4
Heavy Atoms	22
NP-Likeness	-0.73

Activity Summary

IC50 14 meas. best 7.43

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Proto-oncogene tyrosine-protein kinase Src CHEMBL267	IC50	7.43	7.43	37.0	1
DNA-dependent protein kinase catalytic subunit CHEMBL3142	IC50	6.02	6.02	953.0	1
Unchecked CHEMBL612545	IC50	6.0	6.0	1000.0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267	IC50	5.99	5.99	1022.0	1
Tyrosine-protein kinase HCK CHEMBL3234	IC50	5.92	5.92	1200.0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130	IC50	5.7	5.7	2020.0	1
Tyrosine-protein kinase ABL1 CHEMBL1862	IC50	5.58	5.58	2600.0	1
Phosphatidylinositol 4-kinase beta CHEMBL3268	IC50	5.58	5.58	2600.0	1
Ephrin type-B receptor 4 CHEMBL5147	IC50	5.54	5.54	2900.0	1
Epidermal growth factor receptor CHEMBL203	IC50	5.34	5.34	4600.0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform CHEMBL3145	IC50	5.32	5.32	4750.0	1
Vascular endothelial growth factor receptor 2 CHEMBL279	IC50	5.16	5.16	6900.0	1
Serine/threonine-protein kinase mTOR CHEMBL2842	IC50	5.1	5.1	8000.0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005	IC50	5.01	5.01	9850.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Proto-oncogene tyrosine-protein kinase Src	IC50	=	37.0	nM	7.43	Inhibition of recombinant c-Src by radioactive phosphotransfer assay in presence...	18849971
DNA-dependent protein kinase catalytic subunit	IC50	=	953.0	nM	6.02	Inhibition of DNA-PK by radioactive phosphotransfer assay in presence of 10 uM A...	18849971
Unchecked	IC50	=	1000.0	nM	6.0	Inhibition of recombinant c-Src T338I mutant by radioactive phosphotransfer assa...	18849971
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IC50	=	1022.0	nM	5.99	Inhibition of recombinant PI3Kgamma by radioactive phosphotransfer assay in pres...	18849971
Tyrosine-protein kinase HCK	IC50	=	1200.0	nM	5.92	Inhibition of recombinant HCK by radioactive phosphotransfer assay in presence o...	18849971
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	2020.0	nM	5.7	Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in pres...	18849971
Phosphatidylinositol 4-kinase beta	IC50	=	2600.0	nM	5.58	Inhibition of recombinant PI4Kbeta by radioactive phosphotransfer assay in prese...	18849971
Tyrosine-protein kinase ABL1	IC50	=	2600.0	nM	5.58	Inhibition of recombinant c-Abl by radioactive phosphotransfer assay in presence...	18849971
Ephrin type-B receptor 4	IC50	=	2900.0	nM	5.54	Inhibition of recombinant EphB4R by radioactive phosphotransfer assay in presenc...	18849971
Epidermal growth factor receptor	IC50	=	4600.0	nM	5.34	Inhibition of recombinant EGFR by radioactive phosphotransfer assay in presence ...	18849971
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC50	=	4750.0	nM	5.32	Inhibition of recombinant PI3Kbeta by radioactive phosphotransfer assay in prese...	18849971
Vascular endothelial growth factor receptor 2	IC50	=	6900.0	nM	5.16	Inhibition of recombinant VEGFR2 by radioactive phosphotransfer assay in presenc...	18849971
Serine/threonine-protein kinase mTOR	IC50	=	8000.0	nM	5.1	Inhibition of recombinant mTOR by radioactive phosphotransfer assay in presence ...	18849971
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IC50	=	9850.0	nM	5.01	Inhibition of recombinant PI3Kalpha by radioactive phosphotransfer assay in pres...	18849971

Literature References

PubMed	DOI	Target Context	# Activities
18849971	10.1038/nchembio.117	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	1
18849971	10.1038/nchembio.117	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
18849971	10.1038/nchembio.117	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	1
18849971	10.1038/nchembio.117	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	1
18849971	10.1038/nchembio.117	Serine/threonine-protein kinase mTOR	1
18849971	10.1038/nchembio.117	DNA-dependent protein kinase catalytic subunit	1
18849971	10.1038/nchembio.117	Phosphatidylinositol 4-kinase beta	1
18849971	10.1038/nchembio.117	Tyrosine-protein kinase ABL1	1
18849971	10.1038/nchembio.117	Tyrosine-protein kinase HCK	1
18849971	10.1038/nchembio.117	Proto-oncogene tyrosine-protein kinase Src	1
18849971	10.1038/nchembio.117	Unchecked	1
18849971	10.1038/nchembio.117	Vascular endothelial growth factor receptor 2	1
18849971	10.1038/nchembio.117	Epidermal growth factor receptor	1
18849971	10.1038/nchembio.117	Ephrin type-B receptor 4	1

Data from ChEMBL 36 via Core Engine