Compound Detail
CHEMBL4538174
ERKi Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL4538174 |
| Name | ERKi |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RAXZSEGXMBWYQK-SNVBAGLBSA-N |
24
Targets
56
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
2.33
ALogP
4
HBA
4
HBD
102.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 28 meas. best 8.74
Kd 26 meas. best 8.82
EC50 2 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 3 CHEMBL3385 | Kd | 8.82 | 8.82 | 1.5 | 2 |
| Mitogen-activated protein kinase 1 CHEMBL4040 | IC50 | 8.74 | 6.9191 | 1.8 | 11 |
| Mitogen-activated protein kinase 1 CHEMBL4040 | Kd | 8.32 | 8.32 | 4.8 | 2 |
| Mitogen-activated protein kinase 15 CHEMBL5198 | Kd | 7.52 | 7.52 | 30.0 | 2 |
| Unchecked CHEMBL612545 | EC50 | 7.5 | 7.26 | 32.0 | 2 |
| TGF-beta receptor type-2 CHEMBL4267 | Kd | 7.27 | 7.27 | 54.0 | 2 |
| Serine/threonine-protein kinase LATS2 CHEMBL5907 | Kd | 7.26 | 7.26 | 55.0 | 2 |
| Rho-associated protein kinase 2 CHEMBL2973 | Kd | 7.09 | 7.09 | 82.0 | 2 |
| Rho-associated protein kinase 1 CHEMBL3231 | Kd | 7.01 | 7.01 | 98.0 | 2 |
| Beta-adrenergic receptor kinase 1 CHEMBL4079 | Kd | 6.96 | 6.96 | 110.0 | 2 |
| Serine/threonine-protein kinase haspin CHEMBL1075163 | Kd | 6.89 | 6.89 | 130.0 | 2 |
| Serine/threonine-protein kinase ULK1 CHEMBL6006 | Kd | 6.85 | 6.85 | 140.0 | 2 |
| G protein-coupled receptor kinase 3 CHEMBL1075166 | Kd | 6.85 | 6.85 | 140.0 | 2 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | IC50 | 6.68 | 6.68 | 210.0 | 1 |
| Mitogen-activated protein kinase 3 CHEMBL3385 | IC50 | 6.67 | 5.92 | 214.0 | 2 |
| Cyclin-dependent kinase 7 CHEMBL3055 | Kd | 6.64 | 6.64 | 230.0 | 2 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Kd | 6.64 | 6.64 | 230.0 | 2 |
| Serine/threonine-protein kinase Sgk1 CHEMBL2343 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL4079 | IC50 | 6.23 | 6.23 | 590.0 | 1 |
| Serine/threonine-protein kinase TBK1 CHEMBL5408 | IC50 | 6.11 | 6.11 | 770.0 | 1 |
| Cyclin-dependent kinase 2 CHEMBL301 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.07 | 5.62 | 850.0 | 2 |
| Serine/threonine-protein kinase 26 CHEMBL5941 | IC50 | 6.06 | 6.06 | 880.0 | 1 |
| Dual specificity protein kinase CLK2 CHEMBL4225 | IC50 | 6.03 | 6.03 | 940.0 | 1 |
| cGMP-dependent protein kinase 2 CHEMBL2896 | IC50 | 6.02 | 6.02 | 950.0 | 1 |
| Cyclin-dependent kinase 5 CHEMBL4036 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Rho-associated protein kinase 1 CHEMBL3231 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Serine/threonine-protein kinase MARK2 CHEMBL3831 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Rho-associated protein kinase 2 CHEMBL2973 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4507286 | Tyrosine-protein kinase ABL1 | 15 |
| - | 10.6019/CHEMBL4507286 | Unchecked | 12 |
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4507286 | Epidermal growth factor receptor | 12 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4507286 | Mitogen-activated protein kinase 1 | 11 |
| - | 10.6019/CHEMBL4507286 | Receptor-type tyrosine-protein kinase FLT3 | 11 |
| - | 10.6019/CHEMBL4689842 | U2OS | 10 |
| - | 10.6019/CHEMBL4507286 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 10 |
| - | 10.6019/CHEMBL4507286 | Mast/stem cell growth factor receptor Kit | 9 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 8 |
| - | 10.6019/CHEMBL5724696 | U2OS | 8 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL4507286 | Proto-oncogene tyrosine-protein kinase receptor Ret | 4 |
| - | 10.6019/CHEMBL4689842 | HEK-293T | 3 |
| - | 10.6019/CHEMBL4507286 | Rho-associated protein kinase 2 | 3 |
| - | 10.6019/CHEMBL4507286 | Hepatocyte growth factor receptor | 3 |
| - | 10.6019/CHEMBL4507286 | Beta-adrenergic receptor kinase 1 | 3 |
| - | 10.6019/CHEMBL4507286 | ALK tyrosine kinase receptor | 3 |
Data from ChEMBL 36 via Core Engine